(bis ak' oh dil).
Phenol, 4,4¢-(2-pyridinylmethylene)bis-, diacetate (ester).
4,4¢-(2-Pyridylmethylene)diphenol diacetate (ester) [603-50-9].
» Bisacodyl contains not less than 98.0 percent and not more than 101.0 percent of C22H19NO4, calculated on the dried basis.
[CautionAvoid inhalation and contact with the eyes, skin, and mucous membranes. ]
Packaging and storage Preserve in well-closed containers.
USP Reference standards 11
A: Infrared Absorption 197S
Cell: 1.0 mm.
Solution: 1 in 200 solution in chloroform, previously dried.
B: Ultraviolet Absorption 197U
Solution: 20 µg per mL.
Medium: 0.05 N hydrochloric acid.
Absorptivities at 263 nm, calculated on the dried basis, do not differ by more than 3.0%.
Melting range 741: between 131 and 135.
Loss on drying 731 Dry it at 105 for 2 hours: it loses not more than 0.5% of its weight.
Residue on ignition 281: not more than 0.1%.
Heavy metals, Method II 231: 0.001%.
Assay Dissolve about 250 mg of Bisacodyl, accurately weighed, in 70 mL of glacial acetic acid, add 3 drops of p-naphtholbenzein TS, and titrate with 0.1 N perchloric acid VS. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 36.14 mg of C22H19NO4.
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USP35NF30 Page 2364Pharmacopeial Forum: Volume No. 37(3)