Xanthan Gum Solution
» Prepare Xanthan Gum Solution of the designated percentage strength as follows (see Pharmaceutical CompoundingNonsterile Preparations 795):
Dissolve an accurately weighed quantity of Propylparaben in Purified Water with heating to about 50 and stirring. Cool, and dilute quantitatively, and stepwise if necessary, with Purified Water to obtain 90 mL of solution containing 20 mg of Propylparaben. Heat to about 50, and add the Methylparaben, with stirring, to dissolve. Cool, stir with a blender, slowly sift the Xanthan Gum into the vortex, and continue to blend for 2 minutes after the Xanthan Gum has been added. Add 10 mL of Purified Water, and blend for 5 minutes. Allow to stand for 1 hour for excess foam to subside, and remove most of the remaining foam by passing the solution through a strainer. Add Purified Water, if necessary, to make the final volume 100 mL, and stir. [noteDepending on the volume needed and the equipment available, adjust the formula proportionately. ]
Packaging and storage
Preserve in tight, light-resistant containers, and store at controlled room temperature.
Labeling
Label it to state, as part of the official title, the percentage content of xanthan gum.
Beyond-use date
Six weeks after the day on which it was compounded.
Auxiliary Information
Please check for your question in the FAQs before contacting USP.
USP35NF30 Page 2018
Pharmacopeial Forum: Volume No. 28(2) Page 429
|