Vanillin
(van' il in).
DEFINITION
Vanillin contains NLT 97.0% and NMT 103.0% of vanillin (C8H8O3), calculated on the dried basis.
IDENTIFICATION
• B. Ultraviolet Absorption 197U
Sample solution:
8 µg/mL in methanol
Acceptance criteria:
Meets the requirements
ASSAY
• Procedure
Standard solution:
8 µg/mL of USP Vanillin RS in methanol
Sample solution:
8 µg/mL of Vanillin in methanol
Blank:
Methanol
Instrumental conditions
Mode:
UV
Analytical wavelength:
308 nm
Cell:
1 cm
Analysis
Samples:
Standard solution, Sample solution, and Blank
Calculate the percentage of vanillin (C8H8O3) in the portion of Vanillin taken:
Result = (AU/AS) × (CS/CU) × 100
Acceptance criteria:
97.0%103.0% on the dried basis
IMPURITIES
• Residue on Ignition 281:
NMT 0.05%
SPECIFIC TESTS
• Melting Range or Temperature 741:
8183
• Loss on Drying 731:
Dry the sample over silica gel for 4 h: it loses NMT 1.0% of its weight.
ADDITIONAL REQUIREMENTS
• Packaging and Storage:
Preserve in tight, light-resistant containers.
Auxiliary Information
Please check for your question in the FAQs before contacting USP.
USP35NF30 Page 2013
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