Betaine Hydrochloride
(bee' ta een hye'' droe klor' ide).
+'&img=../../images/v35300/g-78.gif&casNumber=590-46-5&usp=35&nf=30&chemicalStructureImage=true&ID='+parent.myID,600,500);)
153.61Methanaminium, 1-carboxy-N, N, N-trimethyl-, chloride.
Betaine hydrochloride.
(Carboxymethyl)trimethylammonium chloride
[590-46-5].» Betaine Hydrochloride contains not less than 98.0 percent and not more than 100.5 percent of C5 H11NO2·HCl, calculated on the anhydrous basis.
Packaging and storage—
Preserve in well-closed containers.
USP Reference standards 
11
—
11—
USP Betaine Hydrochloride RS 
') + '&img=../../images/v35300/cas-590-46-5.gif',600,500);)
Identification—
B:
A solution (1 in 20) responds to the tests for Chloride 191.
191.
pH 791:
between 0.8 and 1.2, in a solution (1 in 4).
791:
between 0.8 and 1.2, in a solution (1 in 4).
Water, Method I 921:
not more than 0.5%.
921:
not more than 0.5%.
Residue on ignition 281:
not more than 0.1%.
281:
not more than 0.1%.
Heavy metals 231:
0.001%.
231:
0.001%.
Assay—
Transfer about 400 mg of Betaine Hydrochloride, accurately weighed, to a conical flask, add 50 mL of glacial acetic acid, and heat gently with swirling until solution is complete. Add 25 mL of mercuric acetate TS, cool, add 2 drops of crystal violet TS, and titrate with 0.1 N perchloric acid VS to a green endpoint. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 15.36 mg of C5H11NO2·HCl.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
|---|---|---|
| Monograph | Elena Gonikberg, Ph.D.
Principal Scientific Liaison 1-301-816-8251 |
(SM32010) Monographs - Small Molecules 3 |
| Reference Standards | RS Technical Services 1-301-816-8129 rstech@usp.org |
USP35–NF30 Page 2335