Trolamine
(troe' la meen).
C6H15NO3
149.19
149.19Ethanol, 2,2¢,2¢¢-nitrilotris-.
2,2¢,2¢¢-Nitrilotriethanol
[102-71-6].» Trolamine is a mixture of alkanolamines consisting largely of triethanolamine [N(C2H4OH)3] containing some diethanolamine [NH(C2H4OH)2] and monoethanolamine [NH2(C2H4OH)]. It contains not less than 99.0 percent and not more than 107.4 percent of alkanolamines, calculated on the anhydrous basis as N(C2H4OH)3.
Packaging and storage—
Preserve in tight, light-resistant containers.
USP Reference standards 
11
—
11—
USP Trolamine RS 
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Identification—
B:
To 1 mL add 0.1 mL of cupric sulfate TS: a deep blue color is produced. Add 5 mL of 1 N sodium hydroxide, and concentrate to one-third of the original volume by boiling: the blue color remains.
C:
To 1 mL add 0.3 mL of cobaltous chloride TS: a carmine red color is produced.
Specific gravity 841:
between 1.120 and 1.128.
841:
between 1.120 and 1.128.
Refractive index 831:
between 1.481 and 1.486 at 20
.
831:
between 1.481 and 1.486 at 20.
Water, Method I 921:
not more than 0.5%, a mixture of 5.0 mL of glacial acetic acid and 20 mL of methanol being used as the solvent.
921:
not more than 0.5%, a mixture of 5.0 mL of glacial acetic acid and 20 mL of methanol being used as the solvent.
Residue on ignition 281:
not more than 0.05%.
281:
not more than 0.05%.
Assay—
Transfer about 2 g of Trolamine, accurately weighed, to a 300-mL conical flask. Add 75 mL of water and 2 drops of methyl red TS, and titrate with 1 N hydrochloric acid VS: each mL of 1 N hydrochloric acid is equivalent to 149.2 mg of triethanolamine, expressed as N(C2H4OH)3.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
|---|---|---|
| Monograph | Robert H. Lafaver, M.S.
Scientific Liaison 1-301-816-8335 |
(EXC2010) Monographs - Excipients |
| Reference Standards | RS Technical Services 1-301-816-8129 rstech@usp.org |
USP35–NF30 Page 2011
Pharmacopeial Forum: Volume No. 31(5) Page 1427