Triflupromazine
(trye'' floo proe' ma zeen).
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352.4210H-Phenothiazine-10-propanamine, N, N-dimethyl-2-(trifluoromethyl)-.
10-3-(Dimethylamino)propyl-2-(trifluoromethyl)phenothiazine
[146-54-3].» Triflupromazine contains not less than 97.0 percent and not more than 103.0 percent of C18H19F3N2S.
Packaging and storage—
Preserve in tight, light-resistant containers.
USP Reference standards 
11
—
11—
USP Triflupromazine Hydrochloride RS 
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[note—Throughout the following procedures, protect test or assay specimens, the Reference Standard, and solutions containing them, by conducting the procedures without delay, under subdued light, or using low-actinic glassware. ]
Identification—
A:
It meets the requirements under Identification—Organic Nitrogenous Bases 181, USP Triflupromazine Hydrochloride RS being used, and 0.01 N hydrochloric acid being used in place of water to dissolve the specimen.
181, USP Triflupromazine Hydrochloride RS being used, and 0.01 N hydrochloric acid being used in place of water to dissolve the specimen.
Solution:
7 µg per mL.
Medium:
0.5 N sulfuric acid.
Absorptivities at 255 nm do not differ by more than 3.0%.
Residue on ignition 281:
not more than 0.2%.
281:
not more than 0.2%.
Ordinary impurities 466—
466—
Test solution:
acetone.
Standard solution:
acetone.
Eluant:
a mixture of chloroform and methanol (4:1).
Visualization:
1.
Assay—
Dissolve about 800 mg of Triflupromazine, accurately weighed, in 100 mL of glacial acetic acid. Add crystal violet TS, and titrate with 0.1 N perchloric acid VS to a blue endpoint. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 35.24 mg of C18H19F3N2S.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
|---|---|---|
| Monograph | Hariram Ramanathan, M.S.
Associate Scientific Liaison 1-301-816-8313 |
(SM42010) Monographs - Small Molecules 4 |
| Reference Standards | RS Technical Services 1-301-816-8129 rstech@usp.org |
USP35–NF30 Page 4944