Sodium Propionate
C3H5NaO2·xH2O
C3H5NaO2 96.06
Propanoic acid, sodium salt, hydrate;
Sodium propionate hydrate
[6700-17-0].
Anhydrous[137-40-6].
(soe' dee um proe' pee oh nate).
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C3H5NaO2·xH2O
C3H5NaO2 96.06
Propanoic acid, sodium salt, hydrate;
Sodium propionate hydrate
[6700-17-0].Anhydrous
[137-40-6].DEFINITION
Sodium Propionate, dried at 105
for 2 h, contains NLT 99.0% and NMT 100.5% of sodium propionate (C3H5NaO2).
for 2 h, contains NLT 99.0% and NMT 100.5% of sodium propionate (C3H5NaO2).IDENTIFICATION
• A. Infrared Absorption 
197K
197K
Analysis:
Perform test on an undried sample.
Acceptance criteria:
Meets the requirements
• B. Identification Tests—General, Sodium 191
191
Sample solution:
1 in 20
Acceptance criteria:
Meets the requirements
ASSAY
• Procedure
Sample:
200 mg of Sodium Propionate, previously dried at 105 for 2 h
for 2 h
Titrimetric system
(See Titrimetry 541.)
541.)
Mode:
Direct titration
Titrant:
0.1 N perchloric acid VS
Blank:
50 mL of glacial acetic acid
Endpoint detection:
Visual
Analysis:
Dissolve the Sample in 50 mL of glacial acetic acid, and add 1 drop of crystal violet TS. Titrate with 0.1 N perchloric acid VS to a green endpoint. Perform a blank determination, and make any necessary correction.
Calculate the percentage of sodium propionate (C3H5NaO2) in the Sample taken:
Result = [(VS 
VB) × N × F × 100]/W
VB) × N × F × 100]/W
| VS | = | = volume of the Titrant consumed by the Sample (mL) |
| VB | = | = volume of the Titrant consumed by the Blank (mL) |
| N | = | = actual normality of the Titrant (mEq/mL) |
| F | = | = equivalency factor, 96.06 mg/mEq |
| W | = | = weight of the Sample (mg) |
Acceptance criteria:
99.0%–100.5% on the dried basis
IMPURITIES
• Heavy Metals, Method I 231
231
Test preparation:
Dissolve 2 g of Sodium Propionate in 1 mL of 1 N acetic acid and sufficient water to make 25 mL.
Acceptance criteria:
NMT 10 ppm
SPECIFIC TESTS
• Water Determination, Method I 921:
NMT 1.0%
921:
NMT 1.0%
• Alkalinity
Sample solution:
2.0 g of Sodium Propionate in 20 mL of water
Analysis:
Add phenolphthalein TS to the Sample solution.
Acceptance criteria:
If a pink color is produced, it is discharged by 0.60 mL of 0.10 N sulfuric acid.
ADDITIONAL REQUIREMENTS
• Packaging and Storage:
Preserve in tight containers.
• USP Reference Standards 11
11
USP Sodium Propionate RS 
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Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
|---|---|---|
| Monograph | Robert H. Lafaver, M.S.
Scientific Liaison 1-301-816-8335 |
(EXC2010) Monographs - Excipients |
| Reference Standards | RS Technical Services 1-301-816-8129 rstech@usp.org |
USP35–NF30 Page 1958