Sodium Polystyrene Sulfonate Suspension
» Sodium Polystyrene Sulfonate Suspension is a suspension of Sodium Polystyrene Sulfonate in an aqueous vehicle that may contain suitable suspending or stabilizing agents. It exchanges not less than 110 mg and not more than 135 mg of potassium for each g of the labeled amount of sodium polystyrene sulfonate.
Packaging and storage—
Preserve in well-closed containers, protected from freezing and from excessive heat.
Microbial enumeration tests 
61
and Tests for specified microorganisms 62—
Its total aerobic microbial count does not exceed 100 cfu per mL, its total combined molds and yeasts count does not exceed 100 cfu per mL, and it meets the requirements of the test for absence of Pseudomonas aeruginosa.
61 and Tests for specified microorganisms 62—
Its total aerobic microbial count does not exceed 100 cfu per mL, its total combined molds and yeasts count does not exceed 100 cfu per mL, and it meets the requirements of the test for absence of Pseudomonas aeruginosa.
Sodium content—
Sodium solution and Standard graph—
Prepare as directed in the test for Sodium content under Sodium Polystyrene Sulfonate.
Procedure—
Transfer an accurately measured quantity of Suspension, freshly mixed and free from air bubbles, equivalent to about 1 g of sodium polystyrene sulfonate, to a suitable crucible, heat at 80
until dry, and ash the residue with a slight excess of sulfuric acid. Proceed as directed for Procedure in the test for Sodium content under Sodium Polystyrene Sulfonate, beginning with “Add 1 mL of nitric acid.” Calculate the percentage of sodium taken by the formula:
until dry, and ash the residue with a slight excess of sulfuric acid. Proceed as directed for Procedure in the test for Sodium content under Sodium Polystyrene Sulfonate, beginning with “Add 1 mL of nitric acid.” Calculate the percentage of sodium taken by the formula:
A / L
in which A is the quantity, in mg, of sodium found per liter, and L is the quantity, in g, of sodium polystyrene sulfonate in the portion of Suspension taken, based on the labeled amount: the sodium content is not less than 9.4% and not more than 11.5%.
Potassium exchange capacity—
Potassium solution, Sodium solution, and Standard graph—
Prepare as directed in the test for Potassium exchange capacity under Sodium Polystyrene Sulfonate.
Procedure—
Transfer an accurately measured quantity of Suspension, freshly mixed and free from air bubbles, equivalent to about 1.6 g of sodium polystyrene sulfonate, to a suitable glass-stoppered flask, add 100.0 mL of Potassium solution, shake by mechanical means for 15 minutes, filter, and discard the first 20 mL of the filtrate. Proceed as directed for Procedure in the test for Potassium exchange capacity under Sodium Polystyrene Sulfonate, beginning with “Pipet 5 mL of the filtrate.” Calculate the quantity, in mg, of potassium adsorbed on each g of the sodium polystyrene sulfonate taken by the formula:
(X 
20Y) / L
in which X is the quantity, in mg, of potassium in 100 mL of Potassium solution before exchange; Y is the quantity, in mg, of potassium per L as interpolated from the Standard graph; and L is the labeled quantity, in g, of sodium polystyrene sulfonate in the portion of Suspension taken.
20Y) / L
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
|---|---|---|
| Monograph | Ravi Ravichandran, Ph.D.
Principal Scientific Liaison 1-301-816-8330 |
(SM42010) Monographs - Small Molecules 4 |
| 61 |
Radhakrishna S Tirumalai, Ph.D.
Principal Scientific Liaison 1-301-816-8339 |
(GCM2010) General Chapters - Microbiology |
| 62 |
Radhakrishna S Tirumalai, Ph.D.
Principal Scientific Liaison 1-301-816-8339 |
(GCM2010) General Chapters - Microbiology |
USP35–NF30 Page 4670
Pharmacopeial Forum: Volume No. 31(4) Page 1115