Sodium Bicarbonate Tablets
» Sodium Bicarbonate Tablets contain not less than 95.0 percent and not more than 105.0 percent of the labeled amount of NaHCO3.
Packaging and storage—
Preserve in well-closed containers.
Identification—
A solution of Tablets responds to the tests for Sodium 
191
and for Bicarbonate 191.
191 and for Bicarbonate 191.
Disintegration 701:
30 minutes, simulated gastric fluid TS being substituted for water in the test.
701:
30 minutes, simulated gastric fluid TS being substituted for water in the test.
Uniformity of dosage units 905:
meet the requirements.
905:
meet the requirements.
Assay—
Weigh and finely powder not less than 20 Tablets. Weigh accurately a portion of the powder, equivalent to about 2 g of sodium bicarbonate, dissolve in 100 mL of water, add methyl red TS, and titrate with 1 N hydrochloric acid VS. Add the acid slowly, with constant stirring, until the solution becomes faintly pink. Heat the solution to boiling, cool, and continue the titration until the pink color no longer fades after boiling. Each mL of 1 N hydrochloric acid is equivalent to 84.01 mg of NaHCO3.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
|---|---|---|
| Monograph | Elena Gonikberg, Ph.D.
Principal Scientific Liaison 1-301-816-8251 |
(SM32010) Monographs - Small Molecules 3 |
| 701 |
Margareth R.C. Marques, Ph.D.
Senior Scientific Liaison 1-301-816-8106 |
(GCDF2010) General Chapters - Dosage Forms |
USP35–NF30 Page 4650