Propylthiouracil
(proe'' pil thye'' oh ure' a sil).
4(1H)-Pyrimidinone, 2,3-dihydro-6-propyl-2-thioxo-. 6-Propyl-2-thiouracil [51-52-5]. »Propylthiouracil contains not less than 98.0 percent and not more than 100.5 percent of C7H10N2OS, calculated on the dried basis.
Packaging and storage
Preserve in well-closed, light-resistant containers.
Identification, Infrared Absorption 197K.
Melting range 741:
between 218 and 221.
Loss on drying 731
Dry it at 105 for 2 hours: it loses not more than 0.5% of its weight.
Residue on ignition 281:
not more than 0.1%.
Selenium 291:
0.003%, a 200-mg specimen being used.
Heavy metals, Method II 231:
0.002%.
Ordinary impurities 466
Test solution:
methanol.
Standard solution:
methanol.
Application volume:
10 µL.
Eluant:
a mixture of toluene, ethyl acetate, and formic acid (50:45:5), in a nonequilibrated chamber.
Visualization:
1.
Assay
Weigh accurately about 300 mg of Propylthiouracil, transfer to a 500-mL conical flask, and add 30 mL of water. Add from a buret about 30 mL of 0.1 N sodium hydroxide VS, heat to boiling, and agitate until solution is complete. Wash down any particles on the wall of the flask with a few mL of water, then add about 50 mL of 0.1 N silver nitrate while mixing, and boil gently for 7 minutes. Cool to room temperature, and continue to titrate with 0.1 N sodium hydroxide VS, determining the endpoint potentiometrically, using a glass-calomel electrode system. Each mL of 0.1 N sodium hydroxide is equivalent to 8.512 mg of C7H10N2OS.
Auxiliary Information
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USP35NF30 Page 4472
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