Propyliodone
(proe'' pil eye' oh done).
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447.011(4H)-Pyridineacetic acid, 3,5-diiodo-4-oxo-, propyl ester.
Propyl 3,5-diiodo-4-oxo-1(4H)pyridineacetate
[587-61-1].» Propyliodone contains not less than 99.0 percent and not more than 101.0 percent of C10H11I2NO3, calculated on the dried basis.
Packaging and storage—
Preserve in tight, light-resistant containers. Store at 25
, excursions permitted between 15 and 30.
, excursions permitted between 15 and 30.
Identification—
A:
Heat 100 mg with a few drops of sulfuric acid: violet vapors are evolved.
B:
Reflux 1 g with 10 mL of 1 N sodium hydroxide for 30 minutes, add 10 mL of water, and acidify to litmus paper with hydrochloric acid: the precipitate of 3,5-diiodo-4-oxo-1(4H)-pyridineacetic acid, after being washed with water and dried at 105, melts at about 245.
, melts at about 245.
Melting range 
741
:
between 187 and 190.
741:
between 187 and 190.
Acidity—
Dissolve 1.0 g in 40 mL of hot n-propyl alcohol previously neutralized to phenolphthalein TS, cool, and allow to stand in an ice bath for 15 minutes with frequent shaking. Filter, wash the residue with neutralized n-propyl alcohol, combine the filtrate and washings, add phenolphthalein TS, and titrate with 0.050 N sodium hydroxide to a pink color that persists for 15 seconds: not more than 0.15 mL of 0.050 N sodium hydroxide is required for neutralization.
Loss on drying 731—
Dry it at 105 to constant weight: it loses not more than 0.5% of its weight.
731—
Dry it at 105 to constant weight: it loses not more than 0.5% of its weight.
Residue on ignition 281:
not more than 0.1%.
281:
not more than 0.1%.
Iodine and iodide—
Shake 2.4 g with 30 mL of water for 15 minutes, filter, and to 10 mL of filtrate add 1 mL of 2 N nitric acid, 1 mL of sodium nitrite solution (1 in 500), and 2 mL of chloroform. Shake, and centrifuge: any purple color in the chloroform layer is not darker than that obtained with a mixture of 6 mL of water and 4 mL of potassium iodide solution (2.6 in 100,000) treated in the same manner (0.01% of I).
Heavy metals, Method II 231:
0.002%.
231:
0.002%.
Assay—
Using about 15 mg of Propyliodone, accurately weighed, proceed as directed in the Assay under Iodoquinol. Each mL of 0.02 N sodium thiosulfate is equivalent to 0.7450 mg of C10H11I2NO3.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
|---|---|---|
| Monograph | Hariram Ramanathan, M.S.
Associate Scientific Liaison 1-301-816-8313 |
(SM42010) Monographs - Small Molecules 4 |
USP35–NF30 Page 4471
Pharmacopeial Forum: Volume No. 29(6) Page 1976