(proe'' klor per' a zeen).
» Prochlorperazine contains not less than 98.0 percent and not more than 101.0 percent of C20H24ClN3S.
Packaging and storage Preserve in tight, light-resistant containers.
USP Reference standards 11
[noteThroughout the following procedures, protect test or assay specimens, the Reference Standard, and solutions containing them, by conducting the procedures without delay, under subdued light, or using low-actinic glassware. ]
Identification It meets the requirements under IdentificationOrganic Nitrogenous Bases 181, USP Prochlorperazine Maleate RS being used as the standard for comparison.
Residue on ignition 281: not more than 0.1%.
Ordinary impurities 466
Test solution: methanol.
Standard solution: methanol.
Eluant: a mixture of methanol and ammonium hydroxide (100:1).
Assay Transfer about 400 mg of Prochlorperazine, accurately weighed, to a 125-mL conical flask, add 30 mL of glacial acetic acid, and warm on a steam bath to dissolve. Add 2 drops of crystal violet TS, and titrate with 0.1 N perchloric acid VS to a blue endpoint. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 18.70 mg of C20H24ClN3S.
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USP35NF30 Page 4428