Prochlorperazine
(proe'' klor per' a zeen).
10H-Phenothiazine, 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-. 2-Chloro-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine [58-38-8]. » Prochlorperazine contains not less than 98.0 percent and not more than 101.0 percent of C20H24ClN3S.
Packaging and storage
Preserve in tight, light-resistant containers.
USP Reference standards 11
[noteThroughout the following procedures, protect test or assay specimens, the Reference Standard, and solutions containing them, by conducting the procedures without delay, under subdued light, or using low-actinic glassware. ]
Identification
It meets the requirements under IdentificationOrganic Nitrogenous Bases 181, USP Prochlorperazine Maleate RS being used as the standard for comparison.
Residue on ignition 281:
not more than 0.1%.
Ordinary impurities 466
Test solution:
methanol.
Standard solution:
methanol.
Eluant:
a mixture of methanol and ammonium hydroxide (100:1).
Visualization:
1.
Assay
Transfer about 400 mg of Prochlorperazine, accurately weighed, to a 125-mL conical flask, add 30 mL of glacial acetic acid, and warm on a steam bath to dissolve. Add 2 drops of crystal violet TS, and titrate with 0.1 N perchloric acid VS to a blue endpoint. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 18.70 mg of C20H24ClN3S.
Auxiliary Information
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USP35NF30 Page 4428
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