Procarbazine Hydrochloride
(proe kar' ba zeen hye'' droe klor' ide).
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257.76Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]-, monohydrochloride.
N-Isopropyl-
-(2-methylhydrazino)-p-toluamide monohydrochloride
[366-70-1].» Procarbazine Hydrochloride contains not less than 98.5 percent and not more than 100.5 percent of C12H19N3O·HCl.
[Caution: Handle Procarbazine Hydrochloride with exceptional care, since it is a highly potent agent.
]
Packaging and storage—
Preserve in tight, light-resistant containers.
USP Reference standards 
11
—
11—
USP Procarbazine Hydrochloride RS 
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Identification—
B:
Ultraviolet Absorption 197U—[note—Use low-actinic glassware throughout this test. ]
197U—[note—Use low-actinic glassware throughout this test. ]
Solution:
10 µg per mL.
Medium:
0.1 N hydrochloric acid.
Absorptivities at 232 nm do not differ by more than 3.0%.
Residue on ignition 281:
not more than 0.1%.
281:
not more than 0.1%.
Heavy metals, Method II 231:
0.002%.
231:
0.002%.
Assay—
Dissolve about 0.75 g of Procarbazine Hydrochloride, accurately weighed, in 100 mL of water. Titrate with 0.1 N sodium hydroxide VS, determining the endpoint potentiometrically, using a calomel-glass electrode system. Each mL of 0.1 N sodium hydroxide is equivalent to 25.78 mg of C12H19N3O·HCl.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
|---|---|---|
| Monograph | Feiwen Mao, M.S.
Senior Scientific Liaison 1-301-816-8320 |
(SM32010) Monographs - Small Molecules 3 |
| Reference Standards | RS Technical Services 1-301-816-8129 rstech@usp.org |
USP35–NF30 Page 4427