Phenoxybenzamine Hydrochloride
(fen ox'' ee ben' za meen hye'' droe klor' ide).
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340.29Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride.
N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride
[63-92-3].» Phenoxybenzamine Hydrochloride contains not less than 98.0 percent and not more than 101.0 percent of C18H22ClNO·HCl, calculated on the dried basis.
Packaging and storage—
Preserve in well-closed containers.
USP Reference standards 
11
—
11—
USP Phenoxybenzamine Hydrochloride RS 
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Identification—
Solution:
1 mg per mL.
Medium:
methanol.
Absorptivities at 275 nm, calculated on the dried basis, do not differ by more than 3.0%.
Melting range, Class I 741:
between 136
and 141.
741:
between 136 and 141.
Loss on drying 731—
Dry it in vacuum at 60 for 2 hours: it loses not more than 0.5% of its weight.
731—
Dry it in vacuum at 60 for 2 hours: it loses not more than 0.5% of its weight.
Ordinary impurities 466—
466—
Test solution:
methanol.
Standard solution:
methanol.
Eluant:
a mixture of toluene and acetone (1:1).
Visualization:
1.
Assay—
Dissolve about 500 mg of Phenoxybenzamine Hydrochloride, accurately weighed, in 50 mL of glacial acetic acid, add 15 mL of mercuric acetate TS, and titrate with 0.1 N perchloric acid VS, determining the endpoint potentiometrically. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 34.03 mg of C18H22ClNO·HCl.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
|---|---|---|
| Monograph | Sujatha Ramakrishna, Ph.D.
Senior Scientific Liaison 1-301-816-8349 |
(SM22010) Monographs - Small Molecules 2 |
| Reference Standards | RS Technical Services 1-301-816-8129 rstech@usp.org |
USP35–NF30 Page 4290