Aspirin Effervescent Tablets for Oral Solution
» Aspirin Effervescent Tablets for Oral Solution contain Aspirin and an effervescent mixture of a suitable organic acid and an alkali metal bicarbonate and/or carbonate. Tablets contain not less than 90.0 percent and not more than 110.0 percent of the labeled amount of aspirin (C9H8O4).
Packaging and storage Preserve in tight containers.
USP Reference standards 11
A: Dissolve 1 Tablet in about 50 mL of 1 N hydrochloric acid, boil for about 5 minutes, and allow to cool. To 2 mL of the resulting solution add 2 or 3 drops of ferric chloride TS: a violet-red color is produced.
B: Add about one-half a Tablet to 50 mL of water in a flask, and immediately stopper with a stopper fitted with tubing so that the evolved gas passes through calcium hydroxide TS: a white precipitate forms.
Solution time Two Tablets dissolve completely in 180 mL of water at 17.5 ± 2.5 within 5 minutes.
Uniformity of dosage units 905: meet the requirements.
Acid-neutralizing capacity 301: not less than 5.0 mEq of acid is consumed by 1 Tablet.
Limit of free salicylate Proceed as directed for Limit of free salicylic acid under Buffered Aspirin Tablets: not more than 8.0% is found.
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USP35NF30 Page 2251