Aspirin Effervescent Tablets for Oral Solution
» Aspirin Effervescent Tablets for Oral Solution contain Aspirin and an effervescent mixture of a suitable organic acid and an alkali metal bicarbonate and/or carbonate. Tablets contain not less than 90.0 percent and not more than 110.0 percent of the labeled amount of aspirin (C9H8O4).
Packaging and storage—
Preserve in tight containers.
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Identification—
A:
Dissolve 1 Tablet in about 50 mL of 1 N hydrochloric acid, boil for about 5 minutes, and allow to cool. To 2 mL of the resulting solution add 2 or 3 drops of ferric chloride TS: a violet-red color is produced.
B:
Add about one-half a Tablet to 50 mL of water in a flask, and immediately stopper with a stopper fitted with tubing so that the evolved gas passes through calcium hydroxide TS: a white precipitate forms.
Solution time—
Two Tablets dissolve completely in 180 mL of water at 17.5 ± 2.5
within 5 minutes.
within 5 minutes.
Uniformity of dosage units 
905
:
meet the requirements.
905:
meet the requirements.
Acid-neutralizing capacity 301:
not less than 5.0 mEq of acid is consumed by 1 Tablet.
301:
not less than 5.0 mEq of acid is consumed by 1 Tablet.
Limit of free salicylate—
Proceed as directed for Limit of free salicylic acid under Buffered Aspirin Tablets: not more than 8.0% is found.
Assay—
Proceed as directed in the Assay under Buffered Aspirin Tablets.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
|---|---|---|
| Monograph | Clydewyn M. Anthony, Ph.D.
Senior Scientific Liaison 1-301-816-8139 |
(SM22010) Monographs - Small Molecules 2 |
| Reference Standards | RS Technical Services 1-301-816-8129 rstech@usp.org |
USP35–NF30 Page 2251