Neomycin and Polymyxin B Sulfates and Hydrocortisone Acetate Cream
» Neomycin and Polymyxin B Sulfates and Hydrocortisone Acetate Cream contains the equivalent of not less than 90.0 percent and not more than 130.0 percent of the labeled amounts of neomycin and polymyxin B, and not less than 90.0 percent and not more than 110.0 percent of the labeled amount of hydrocortisone acetate (C23H32O6).
Packaging and storage—
Preserve in well-closed containers.
USP Reference standards 
11
—
11—
USP Hydrocortisone Acetate RS 
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USP Neomycin Sulfate RS
USP Polymyxin B Sulfate RS
Identification—
A:
It meets the requirements under Thin-Layer Chromatographic Identification Test 201BNP.
201BNP.
B:
The retention time of the major peak for hydrocortisone acetate in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay for hydrocortisone acetate.
Minimum fill 755:
meets the requirements.
755:
meets the requirements.
Assay for neomycin and Assay for polymyxin B—
Proceed with Cream as directed in the Assay for neomycin and in the Assay for polymyxin B under Neomycin and Polymyxin B Sulfates Cream.
Assay for hydrocortisone acetate—
Proceed with Cream as directed in the Assay under Hydrocortisone Acetate Lotion.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
|---|---|---|
| Monograph | Ahalya Wise, M.S.
Senior Scientific Liaison 1-301-816-8161 |
(SM12010) Monographs - Small Molecules 1 |
| Reference Standards | RS Technical Services 1-301-816-8129 rstech@usp.org |
USP35–NF30 Page 4029
Pharmacopeial Forum: Volume No. 30(2) Page 520