Neomycin and Polymyxin B Sulfates, Gramicidin, and Hydrocortisone Acetate Cream

» Neomycin and Polymyxin B Sulfates, Gramicidin, and Hydrocortisone Acetate Cream contains the equivalent of not less than 90.0 percent and not more than 130.0 percent of the labeled amounts of neomycin, polymyxin B, and gramicidin, and not less than 90.0 percent and not more than 110.0 percent of the labeled amount of hydrocortisone acetate (C23H32O6).

Packaging and storage— Preserve in well-closed containers.

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USP Gramicidin RS

USP Hydrocortisone Acetate RS

USP Neomycin Sulfate RS

USP Polymyxin B Sulfate RS

Minimum fill

755

: meets the requirements.

Assay for neomycin and Assay for polymyxin B— Proceed with Cream as directed in the Assay for neomycin and in the Assay for polymyxin B under Neomycin and Polymyxin B Sulfates and Bacitracin Zinc Ophthalmic Ointment.

Assay for gramicidin— Proceed with Cream as directed in the Assay for gramicidin under Neomycin Sulfate and Gramicidin Ointment.

Assay for hydrocortisone acetate— Proceed with Cream as directed in the Assay under Hydrocortisone Acetate Lotion.

Auxiliary Information— Please check for your question in the FAQs before contacting USP.

Topic/Question	Contact	Expert Committee
Monograph	Ahalya Wise, M.S. Senior Scientific Liaison 1-301-816-8161	(SM12010) Monographs - Small Molecules 1
Reference Standards	RS Technical Services 1-301-816-8129 rstech@usp.org

USP35–NF30 Page 4027

Pharmacopeial Forum: Volume No. 30(2) Page 520