Neomycin Sulfate and Hydrocortisone Cream
» Neomycin Sulfate and Hydrocortisone Cream contains the equivalent of not less than 90.0 percent and not more than 135.0 percent of the labeled amount of neomycin, and not less than 90.0 percent and not more than 110.0 percent of the labeled amount of hydrocortisone (C21H30O5).
Packaging and storage—
Preserve in collapsible tubes or in well-closed containers.
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Identification—
A:
It meets the requirements for neomycin under Thin-Layer Chromatographic Identification Test 
201BNP
.
201BNP.
B:
The retention time of the major peaks for hydrocortisone in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay for hydrocortisone.
Minimum fill 755:
meets the requirements.
755:
meets the requirements.
Assay for neomycin—
Proceed with Cream as directed in the Assay under Neomycin Sulfate Ointment.
Assay for hydrocortisone—
Proceed with Cream as directed in the Assay for hydrocortisone under Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone Ophthalmic Ointment.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
|---|---|---|
| Monograph | Ahalya Wise, M.S.
Senior Scientific Liaison 1-301-816-8161 |
(SM12010) Monographs - Small Molecules 1 |
| Reference Standards | RS Technical Services 1-301-816-8129 rstech@usp.org |
USP35–NF30 Page 4015
Pharmacopeial Forum: Volume No. 28(4) Page 1156