Monothioglycerol
(mon'' oh thye'' oh glis' er ol).
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108.161,2-Propanediol, 3-mercapto-.
3-Mercapto-1,2-propanediol
[96-27-5].» Monothioglycerol contains not less than 97.0 percent and not more than 101.0 percent of C3H8O2S, calculated on the anhydrous basis.
Packaging and storage—
Preserve in tight containers.
Specific gravity 
841
:
between 1.241 and 1.250.
841:
between 1.241 and 1.250.
Refractive index 831:
between 1.521 and 1.526.
831:
between 1.521 and 1.526.
pH 791:
between 3.5 and 7.0, in a solution (1 in 10).
791:
between 3.5 and 7.0, in a solution (1 in 10).
Water, Method II 921:
not more than 5.0%.
921:
not more than 5.0%.
Residue on ignition 281:
not more than 0.1%.
281:
not more than 0.1%.
Selenium 291:
0.003%, a 200-µL test specimen being used.
291:
0.003%, a 200-µL test specimen being used.
Heavy metals, Method II 231:
0.002%.
231:
0.002%.
Assay—
Dissolve about 400 mg of Monothioglycerol, accurately weighed, in 50 mL of water, and titrate with 0.1 N iodine VS, adding 3 mL of starch TS as the endpoint is approached. Each mL of 0.1 N iodine is equivalent to 10.82 mg of C3H8O2S.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
|---|---|---|
| Monograph | Robert H. Lafaver, M.S.
Scientific Liaison 1-301-816-8335 |
(EXC2010) Monographs - Excipients |
USP35–NF30 Page 1872