(meth'' oh trye mep' ra zeen).
10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,-trimethyl-, ()-.
» Methotrimeprazine contains not less than 98.0 percent and not more than 101.0 percent of C19H24N2OS, calculated on the dried basis.
Packaging and storage Preserve in well-closed, light-resistant containers. Store at 25, excursions permitted between 15 and 30.
USP Reference standards 11
[noteThroughout the following procedures, protect test or assay specimens, the USP Reference Standard, and the solutions containing them, by conducting the procedures without delay, under subdued light, or using low-actinic glassware. ]
B: Ultraviolet Absorption 197U
Solution: 7 µg per mL.
Absorptivities at 255 nm, calculated on the dried basis, do not differ by more than 3.0%.
Specific rotation 781S: between 15 and 18.
Test solution: 50 mg per mL, in chloroform.
Loss on drying 731 Dry it at 100 for 3 hours: it loses not more than 0.5% of its weight.
Selenium 291 The absorbance of the solution from the Test Solution, prepared with 100 mg of Methotrimeprazine and 100 mg of magnesium oxide, is not greater than one-half that from the Standard Solution (0.003%).
Assay Dissolve about 700 mg of Methotrimeprazine, accurately weighed, in 100 mL of chloroform, add 1 drop of a 1 in 500 solution of crystal violet in chloroform, and titrate with 0.1 N perchloric acid VS to the first disappearance of the violet tinge. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 32.85 mg of C19H24N2OS.
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USP35NF30 Page 3858Pharmacopeial Forum: Volume No. 29(6) Page 1931