Mesoridazine Besylate
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544.7510H-Phenothiazine, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylsulfinyl)-, (±)-, monobenzenesulfonate.
(±)-10-[2-(1-Methyl-2-piperidyl)ethyl]-2-(methylsulfinyl)phenothiazine monobenzenesulfonate
[32672-69-8].» Mesoridazine Besylate contains not less than 98.0 percent and not more than 102.0 percent of C21H26N2OS2·C6H6O3S, calculated on the dried basis.
Packaging and storage—
Preserve in tight, light-resistant containers.
USP Reference standards 
11
—
11—
USP Mesoridazine Besylate RS 
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[note—Throughout the following procedures, protect test or assay specimens, the USP Reference Standard, and solutions containing them, by conducting the procedures without delay, under subdued light, or using low-actinic glassware. ]
Identification—
B:
Ultraviolet Absorption 197U—
197U—
Solution:
10 µg per mL.
Medium:
methanol.
Absorptivities at 263 nm, calculated on the dried basis, do not differ by more than 3.0%.
pH 791:
between 4.2 and 5.7, in a freshly prepared solution (1 in 100).
791:
between 4.2 and 5.7, in a freshly prepared solution (1 in 100).
Loss on drying 731—
Dry it at 105
for 4 hours: it loses not more than 0.5% of its weight.
731—
Dry it at 105 for 4 hours: it loses not more than 0.5% of its weight.
Residue on ignition 281:
not more than 0.2%.
281:
not more than 0.2%.
Heavy metals, Method II 231:
0.002%.
231:
0.002%.
Selenium 291—
The absorbance of the solution from the Test Solution, prepared with 100 mg of Mesoridazine Besylate and 100 mg of magnesium oxide, is not greater than one-half that from the Standard Solution (0.003%).
291—
The absorbance of the solution from the Test Solution, prepared with 100 mg of Mesoridazine Besylate and 100 mg of magnesium oxide, is not greater than one-half that from the Standard Solution (0.003%).
Ordinary impurities 466—
466—
Test solution:
a solution in methanol having a known concentration of 14.1 mg per mL equivalent to 10 mg of mesoridazine per mL.
Standard solution:
methanol.
Eluant:
a mixture of chloroform, isopropyl alcohol, and ammonium hydroxide (87:12:1).
Visualization:
3, followed by spraying with 3% (v/v) aqueous hydrogen peroxide.
Application volume:
10 µL.
Limit:
3.0%.
Assay—
Dissolve about 150 mg of Mesoridazine Besylate, accurately weighed, in 70 mL of acetic anhydride, and titrate with 0.1 N perchloric acid VS, determining the endpoint potentiometrically. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 27.24 mg of C21H26N2OS2·C6H6O3S.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
|---|---|---|
| Monograph | Hariram Ramanathan, M.S.
Associate Scientific Liaison 1-301-816-8313 |
(SM42010) Monographs - Small Molecules 4 |
| Reference Standards | RS Technical Services 1-301-816-8129 rstech@usp.org |
USP35–NF30 Page 3822
Pharmacopeial Forum: Volume No. 30(4) Page 1262