Manganese Sulfate
MnSO4·H2O 169.02
Sulfuric acid, manganese(2+) salt (1:1) monohydrate;
Manganese(2+) sulfate (1:1) monohydrate
[10034-96-5].
Anhydrous 151.00[7785-87-7].
(man' ga nees sul' fate).
MnSO4·H2O 169.02
Sulfuric acid, manganese(2+) salt (1:1) monohydrate;
Manganese(2+) sulfate (1:1) monohydrate
[10034-96-5].Anhydrous 151.00
[7785-87-7].DEFINITION
Manganese Sulfate contains NLT 98.0% and NMT 102.0% of MnSO4·H2O.
IDENTIFICATION
• A. Identification Tests—General, Manganese 
191
191
Sample solution:
100 mg/mL
Acceptance criteria:
Meets the requirements
• B. Identification Tests—General, Sulfate 191
191
Sample solution:
100 mg/mL
Acceptance criteria:
Meets the requirements
ASSAY
• Procedure
Sample:
350 mg
Analysis:
Dissolve the Sample in 200 mL of water. Add 10 mg of ascorbic acid. Begin the titration by adding 25 mL of 0.05 M edetate disodium VS using a suitable buret, then add 10 mL of ammonia–ammonium chloride buffer TS and 0.15 mL of eriochrome black TS. Complete the titration with 0.05 M edetate disodium VS to a blue endpoint. Each mL of 0.05 M edetate disodium is equivalent to 8.451 mg of MnSO4·H2O.
Acceptance criteria:
98.0%–102.0%
IMPURITIES
• Substances Not Precipitated by Ammonium Sulfide
Sample:
2.0 g
Analysis:
Dissolve the Sample in 90 mL of water, add 5 mL of ammonium hydroxide, warm the solution, and pass hydrogen sulfide through the solution for about 30 min. Dilute with water to 100 mL, mix, and allow the precipitate to settle. Decant the supernatant through a filter, transfer 50 mL of the clear filtrate to a tared dish, evaporate to dryness, and ignite, gently at first and finally at 800 ± 25
.
.
Acceptance criteria:
The weight of the residue does not exceed 5 mg (NMT 0.5%).
SPECIFIC TESTS
• Loss on Ignition 733
733
Analysis:
Ignite a sample at 450 to constant weight: it loses 10.0%–13.0% of its weight.
to constant weight: it loses 10.0%–13.0% of its weight.
ADDITIONAL REQUIREMENTS
• Packaging and Storage:
Preserve in tight containers. Store at controlled room temperature.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
|---|---|---|
| Monograph | Morgan Puderbaugh, B.S.
Associate Scientific Liaison 1-301-998-6833 |
(SM32010) Monographs - Small Molecules 3 |
USP35–NF30 Page 3765
Pharmacopeial Forum: Volume No. 29(6) Page 1922