Anethole
C10H12O 148.20
Benzene, 1-methoxy-4-(1-propenyl)-, (E)-;
(E)-p-Propenylanisole
[4180-23-8].
Synthetic[104-46-1].
(an' e thole).
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C10H12O 148.20
Benzene, 1-methoxy-4-(1-propenyl)-, (E)-;
(E)-p-Propenylanisole
[4180-23-8].Synthetic
[104-46-1].DEFINITION
Anethole is obtained from Anise Oil and other sources, or it is prepared synthetically.
IMPURITIES
• Heavy Metals, Method II 
231
:
NMT 20 ppm
231:
NMT 20 ppm
• Limit of Phenols
Sample:
1 mL
Analysis:
Shake the Sample with 20 mL of water, and allow the liquids to separate. Pass the water layer through a filter paper previously moistened with water, and to 10 mL of the filtrate add 3 drops of ferric chloride TS.
Acceptance criteria:
No purple or purplish color is produced.
• Aldehydes and Ketones
Sample:
10 mL
Analysis:
Shake the Sample with 50 mL of a saturated solution of sodium bisulfite in a graduated cylinder, and allow the mixture to stand for 6 h.
Acceptance criteria:
No appreciable diminution in the volume of Anethole occurs, and no crystalline deposit separates.
SPECIFIC TESTS
• Specific Gravity 841:
0.983–0.988
841:
0.983–0.988
• Congealing Temperature 651:
NLT 20
651:
NLT 20
• Distilling Range, Method I 721:
231–237, a correction factor of 0.063/mm being applied as necessary
721:
231–237, a correction factor of 0.063/mm being applied as necessary
• Optical Rotation, Angular Rotation 781A:
0.15 to +0.15
781A:
0.15 to +0.15
• Refractive Index 831:
1.557–1.561
831:
1.557–1.561
ADDITIONAL REQUIREMENTS
• Packaging and Storage:
Preserve in tight, light-resistant containers.
• Labeling:
Label to indicate whether it is of natural sources or is prepared synthetically.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
|---|---|---|
| Monograph | Robert H. Lafaver, M.S.
Scientific Liaison 1-301-816-8335 |
(EXC2010) Monographs - Excipients |
USP35–NF30 Page 1700