Isoniazid Oral Solution
» Isoniazid Oral Solution contains, in each 100 mL, not less than 0.93 g and not more than 1.10 g of isoniazid (C6H7N3O).
Packaging and storage— Preserve in tight, light-resistant containers.
USP Reference standards 11
USP Isoniazid RS Click to View Structure
Identification— A volume of Oral Solution equivalent to about 50 mg of isoniazid meets the requirements of Identification test B under Isoniazid.
Assay— Transfer an accurately measured volume of Oral Solution, equivalent to about 100 mg of isoniazid, to a 100-mL beaker. Add 50 mL of a mixture of 1 part of potassium bromide in 10 parts of dilute hydrochloric acid (1 in 6), and proceed as directed under Nitrite Titration 451, beginning with “cool to 15.” Each mL of 0.1 M sodium nitrite is equivalent to 13.71 mg of isoniazid (C6H7N3O).
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Monograph Behnam Davani, Ph.D., M.B.A.
Senior Scientific Liaison
(SM12010) Monographs - Small Molecules 1
Reference Standards RS Technical Services
USP35–NF30 Page 3575
Pharmacopeial Forum: Volume No. 28(2) Page 311