Isometheptene Mucate
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492.65Isometheptene, galactarate (2:1) (salt).
6-Methylamino-2-methylheptene, tetrahydroxyadipic acid (2:1) (salt)
[7492-31-1].» Isometheptene Mucate contains not less than 99.0 percent and not more than 103.0 percent of (C9H19N)2·C6H10O8, calculated on the dried basis.
Packaging and storage—
Preserve in well-closed containers.
USP Reference standards 
11
—
11—
USP Isometheptene Mucate RS 
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pH 791:
between 6.0 and 7.5, in a solution (1 in 20).
791:
between 6.0 and 7.5, in a solution (1 in 20).
Loss on drying 731—
Dry it at 60
for 18 hours: it loses not more than 1.0% of its weight.
731—
Dry it at 60 for 18 hours: it loses not more than 1.0% of its weight.
Residue on ignition 281:
not more than 0.1%.
281:
not more than 0.1%.
Assay—
Transfer about 500 mg of Isometheptene Mucate, accurately weighed, to a 125-mL conical flask. Add 25 mL of water, and swirl to dissolve. Add 45.0 mL of 0.1 N bromine VS, attach a 30-mL separator to the conical flask, and evacuate the system. Stir with a magnetic stirrer for 1 hour. Equilibrate the system to atmospheric pressure. Add 5 mL of hydrochloric acid to the separator, and allow 4 mL of it to enter the conical flask. Add 10 mL of potassium iodide TS to the separator, and allow the contents to pass into the conical flask. Immediately titrate the liberated iodine with 0.1 N sodium thiosulfate VS, adding 3 mL of starch TS as the endpoint is approached. Perform a blank titration (see Residual Titrations under Titrimetry 541). Each mL of 0.1 N sodium thiosulfate is equivalent to 12.32 mg of (C9H19N)2·C6H10O8.
541). Each mL of 0.1 N sodium thiosulfate is equivalent to 12.32 mg of (C9H19N)2·C6H10O8.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
|---|---|---|
| Monograph | Hariram Ramanathan, M.S.
Associate Scientific Liaison 1-301-816-8313 |
(SM42010) Monographs - Small Molecules 4 |
| Reference Standards | RS Technical Services 1-301-816-8129 rstech@usp.org |
USP35–NF30 Page 3573