Acetic Acid
(a see' tik as' id).
Acetic acid; Acetic acid [64-19-7]. DEFINITION
Acetic Acid is a solution containing NLT 36.0% and NMT 37.0%, by weight, of C2H4O2.
IDENTIFICATION
• A. Identification TestsGeneral, Acetate 191:
Meets the requirements
ASSAY
• Procedure
Analysis:
Place 6 mL in a tared, glass-stoppered flask, and weigh. Add 40 mL of water, then add phenolphthalein TS. Titrate with 1 N sodium hydroxide VS. Each mL of 1 N sodium hydroxide is equivalent to 60.05 mg of C2H4O2.
Acceptance criteria:
36.0%37.0%
IMPURITIES
• Nonvolatile Residue
Analysis:
Evaporate 20 mL in a tared porcelain dish on a steam bath, and dry at 105 for 1 h.
Acceptance criteria:
The weight of the residue does not exceed 1.0 mg (0.005%).
• Chloride
Sample solution:
Acetic acid (1 in 10) in water
Analysis:
To 10 mL of the Sample solution add 5 drops of silver nitrate TS.
Acceptance criteria:
No opalescence is produced.
• Sulfate
Sample solution:
Acetic acid (1 in 10) in water
Analysis:
To 10 mL of the Sample solution add 5 drops of barium chloride TS.
Acceptance criteria:
No turbidity is produced.
• Heavy Metals 231
Sample solution:
To the residue obtained in the test for Nonvolatile Residue add 8 mL of 0.1 N hydrochloric acid, warm gently until completely dissolved, and dilute with water to 100 mL. Use 10 mL of this solution.
Acceptance criteria:
NMT 10 ppm
• Readily Oxidizable Substances
Analysis:
Dilute 4.0 mL in a glass-stoppered vessel with 20 mL of water, and add 0.30 mL of 0.10 N potassium permanganate.
Acceptance criteria:
The pink color is not changed to brown at once, and the liquid does not become entirely brown or free from a pink tint in less than 30 s.
ADDITIONAL REQUIREMENTS
• Packaging and Storage:
Preserve in tight containers.
Auxiliary Information
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USP35NF30 Page 1681
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