(eye'' dox ure' i deen).
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C9H11IN2O5 354.10

Uridine, 2¢-deoxy-5-iodo-.
2¢-Deoxy-5-iodouridine [54-42-2].
» Idoxuridine contains not less than 98.0 percent and not more than 101.0 percent of C9H11IN2O5, calculated on the dried basis.
Packaging and storage— Preserve in tight, light-resistant containers.
USP Reference standards 11
USP Idoxuridine RS Click to View Structure
B: Ultraviolet Absorption 197U
Solution: 35 µg per mL.
Medium: pH 12.0 buffer (prepared from 7.46 g of potassium chloride and 24 mL of 1 N sodium hydroxide dissolved in 2000 mL of water).
Absorptivities at 279 nm, calculated on the dried basis for the test sample only, do not differ by more than 2.0%.
Loss on drying 731 Dry about 500 mg, accurately weighed, in vacuum at 60 for 2 hours: it loses not more than 1.0% of its weight.
Assay— Dissolve about 250 mg of Idoxuridine, accurately weighed, in 20 mL of dimethylformamide that previously has been neutralized with 0.1 N sodium methoxide in toluene VS, a solution of 300 mg of thymol blue in 100 mL of methanol being used as the indicator. Titrate with 0.1 N sodium methoxide in toluene VS to a blue endpoint, taking precautions against absorption of atmospheric carbon dioxide. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N sodium methoxide is equivalent to 35.41 mg of C9H11IN2O5.
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Monograph Behnam Davani, Ph.D., M.B.A.
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USP35–NF30 Page 3476
Pharmacopeial Forum: Volume No. 29(4) Page 1033