Vehicle for Oral Suspension
» Prepare Vehicle for Oral Suspension as follows (see Pharmaceutical Compounding—Nonsterile Preparations 795).
Cellulose, Microcrystalline 800 mg
Xanthan Gum 200 mg
Carrageenan 150 mg
Carboxymethylcellulose Sodium (High Viscosity) 25 mg
Citric Acid 250 mg
Sodium Phosphate, Dibasic 120 mg
Simethicone 0.1 mL
Potassium Sorbate 100 mg
Methylparaben 100 mg
Purified water, a sufficient quantity to make 100 mL
Calculate the quantity of each ingredient required for the total amount to be prepared. Accurately weigh/measure each ingredient. Heat about 90 mL of the Purified Water to 70 to 75. Dissolve the Methylparaben, followed by the Citric Acid, Dibasic Sodium Phosphate, and Potassium Sorbate in the heated water. Remove from the heat. Constantly mixing, slowly sprinkle on the Microcrystalline Cellulose, Xanthan Gum, Carrageenan, and Carboxymethylcellulose Sodium. Continue to stir until fully hydrated, add the Simethicone, and mix well. Add sufficient Purified Water to volume, and mix well. Adjust the pH if necessary. Package, and label.
Packaging and storage— Package in a tight, light-resistant container, and store at controlled room temperature.
Labeling— Label it to indicate that it is for use in compounding oral solutions and suspensions.
pH 791: an apparent pH between 4.0 and 5.0.
Beyond-use date— See Beyond-use date under Vehicle for Oral Solution, Sugar Free.
Auxiliary Information— Please check for your question in the FAQs before contacting USP.
Topic/Question Contact Expert Committee
Monograph Jeanne H. Sun
Assistant Scientific Liaison
(CMP2010) Compounding
USP35–NF30 Page 1880
Pharmacopeial Forum: Volume No. 29(4) Page 1116