Vehicle for Oral Suspension
» Prepare Vehicle for Oral Suspension as follows (see Pharmaceutical Compounding—Nonsterile Preparations 
795
).
795). | Cellulose, Microcrystalline | 800 mg |
| Xanthan Gum | 200 mg |
| Carrageenan | 150 mg |
| Carboxymethylcellulose Sodium (High Viscosity) | 25 mg |
| Citric Acid | 250 mg |
| Sodium Phosphate, Dibasic | 120 mg |
| Simethicone | 0.1 mL |
| Potassium Sorbate | 100 mg |
| Methylparaben | 100 mg |
| Purified water, a sufficient quantity to make | 100 mL |
Calculate the quantity of each ingredient required for the total amount to be prepared. Accurately weigh/measure each ingredient. Heat about 90 mL of the Purified Water to 70
to 75. Dissolve the Methylparaben, followed by the Citric Acid, Dibasic Sodium Phosphate, and Potassium Sorbate in the heated water. Remove from the heat. Constantly mixing, slowly sprinkle on the Microcrystalline Cellulose, Xanthan Gum, Carrageenan, and Carboxymethylcellulose Sodium. Continue to stir until fully hydrated, add the Simethicone, and mix well. Add sufficient Purified Water to volume, and mix well. Adjust the pH if necessary. Package, and label.
to 75. Dissolve the Methylparaben, followed by the Citric Acid, Dibasic Sodium Phosphate, and Potassium Sorbate in the heated water. Remove from the heat. Constantly mixing, slowly sprinkle on the Microcrystalline Cellulose, Xanthan Gum, Carrageenan, and Carboxymethylcellulose Sodium. Continue to stir until fully hydrated, add the Simethicone, and mix well. Add sufficient Purified Water to volume, and mix well. Adjust the pH if necessary. Package, and label.
Packaging and storage—
Package in a tight, light-resistant container, and store at controlled room temperature.
Labeling—
Label it to indicate that it is for use in compounding oral solutions and suspensions.
pH 791:
an apparent pH between 4.0 and 5.0.
791:
an apparent pH between 4.0 and 5.0.
Beyond-use date—
See Beyond-use date under Vehicle for Oral Solution, Sugar Free.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
|---|---|---|
| Monograph | Jeanne H. Sun
Assistant Scientific Liaison 1-301-816-3361 |
(CMP2010) Compounding |
USP35–NF30 Page 1880
Pharmacopeial Forum: Volume No. 29(4) Page 1116