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C10H12O2 164.20
Phenol, 2-methoxy-4-(2-propenyl)-;    
4-Allyl-2-methoxyphenol     [97-53-0].
Eugenol is obtained from clove oil and from other sources.
•  Heavy Metals, Method II 231: NMT 40 ppm
•  Hydrocarbons
Analysis:  Dissolve 1 mL in 20 mL of 0.5 N sodium hydroxide in a 50-mL stoppered tube, add 18 mL of water, and mix.
Acceptance criteria:  A clear mixture results immediately, but it may become turbid when exposed to air.
•  Limit of Phenol
Analysis:  Shake 1 mL with 20 mL of water, filter, and add 1 drop of ferric chloride TS to 5 mL of the clear filtrate.
Acceptance criteria:  The mixture exhibits a transient grayish green color but not a blue or violet color.
•  Specific Gravity 841: 1.064–1.070
•  Distilling Range, Method II 721: NLT 95% distills from 250–255
•  Refractive Index 831: 1.540–1.542 at 20
•  Solubility in 70% Alcohol: One volume dissolves in 2 volumes of 70% alcohol.
•  Packaging and Storage: Preserve in tight, light-resistant containers.
Auxiliary Information— Please check for your question in the FAQs before contacting USP.
Topic/Question Contact Expert Committee
Monograph Clydewyn M. Anthony, Ph.D.
Senior Scientific Liaison
(SM22010) Monographs - Small Molecules 2
USP35–NF30 Page 3149
Pharmacopeial Forum: Volume No. 37(2)