Eugenol
C10H12O2 164.20
Phenol, 2-methoxy-4-(2-propenyl)-;
4-Allyl-2-methoxyphenol
[97-53-0].
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C10H12O2 164.20
Phenol, 2-methoxy-4-(2-propenyl)-;
4-Allyl-2-methoxyphenol
[97-53-0].DEFINITION
Eugenol is obtained from clove oil and from other sources.
IMPURITIES
• Heavy Metals, Method II 
231
:
NMT 40 ppm
231:
NMT 40 ppm
• Hydrocarbons
Analysis:
Dissolve 1 mL in 20 mL of 0.5 N sodium hydroxide in a 50-mL stoppered tube, add 18 mL of water, and mix.
Acceptance criteria:
A clear mixture results immediately, but it may become turbid when exposed to air.
• Limit of Phenol
Analysis:
Shake 1 mL with 20 mL of water, filter, and add 1 drop of ferric chloride TS to 5 mL of the clear filtrate.
Acceptance criteria:
The mixture exhibits a transient grayish green color but not a blue or violet color.
SPECIFIC TESTS
• Specific Gravity 841:
1.064–1.070
841:
1.064–1.070
• Distilling Range, Method II 721:
NLT 95% distills from 250
–255
721:
NLT 95% distills from 250–255
• Refractive Index 831:
1.540–1.542 at 20
831:
1.540–1.542 at 20
• Solubility in 70% Alcohol:
One volume dissolves in 2 volumes of 70% alcohol.
ADDITIONAL REQUIREMENTS
• Packaging and Storage:
Preserve in tight, light-resistant containers.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
|---|---|---|
| Monograph | Clydewyn M. Anthony, Ph.D.
Senior Scientific Liaison 1-301-816-8139 |
(SM22010) Monographs - Small Molecules 2 |
USP35–NF30 Page 3149
Pharmacopeial Forum: Volume No. 37(2)