Ethyl Vanillin
(eth' il van' il in).
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C9H10O3 166.17
Benzaldehyde, 3-ethoxy-4-hydroxy-;    
3-Ethoxy-4-hydroxybenzaldehyde     [121-32-4].
Ethyl Vanillin, dried over phosphorus pentoxide for 4 h, contains NLT 98.0% and NMT 101.0% of C9H10O3.
•  B. Ultraviolet Absorption 197U
Sample solution:  8 µg/mL in methanol
Acceptance criteria:  Meets the requirements
•  Procedure
Sample:  300 mg of Ethyl Vanillin (previously dried)
Titrimetric system 
Mode:  Direct titration
Titrant:  0.1 N sodium methoxide VS
Blank:  50 mL of dimethylformamide, accurately measured
Endpoint detection:  Visual
Analysis:  Transfer the Sample solution to a 125-mL conical flask, and dissolve in 50 mL of dimethylformamide. Add thymol blue TS and titrate, using a magnetic stirrer and taking precautions against the absorption of atmospheric carbon dioxide. Perform a blank determination. Calculate the percentage of ethyl vanillin (C9H10O3) in the Sample taken:
Result = {[(VS VB) × N × F]/W} × 100
VS== Titrant volume consumed by the Sample (mL)
VB== Titrant volume consumed by the Blank (mL)
N== actual normality of the Titrant (mEq/mL)
F== equivalency factor, 166.2 mg/mEq
W== Sample weight (mg)
Acceptance criteria:  98.0%–101.0% on the previously dried basis
•  Residue on Ignition 281: NMT 0.1%
•  Loss on Drying 731: Dry a sample over phosphorus pentoxide for 4 h: it loses NMT 1.0% of its weight.
•  Packaging and Storage: Preserve in tight, light-resistant containers.
•  USP Reference Standards 11
USP Ethyl Vanillin RS Click to View Structure
Auxiliary Information— Please check for your question in the FAQs before contacting USP.
Topic/Question Contact Expert Committee
Monograph Robert H. Lafaver, M.S.
Scientific Liaison
(EXC2010) Monographs - Excipients
Reference Standards RS Technical Services
USP35–NF30 Page 1794