Ethyl Vanillin
(eth' il van' il in).
DEFINITION
Ethyl Vanillin, dried over phosphorus pentoxide for 4 h, contains NLT 98.0% and NMT 101.0% of C9H10O3.
IDENTIFICATION
• B. Ultraviolet Absorption 197U
Sample solution:
8 µg/mL in methanol
Acceptance criteria:
Meets the requirements
ASSAY
• Procedure
Sample:
300 mg of Ethyl Vanillin (previously dried)
Titrimetric system
(See Titrimetry 541.)
Mode:
Direct titration
Titrant:
0.1 N sodium methoxide VS
Blank:
50 mL of dimethylformamide, accurately measured
Endpoint detection:
Visual
Analysis:
Transfer the Sample solution to a 125-mL conical flask, and dissolve in 50 mL of dimethylformamide. Add thymol blue TS and titrate, using a magnetic stirrer and taking precautions against the absorption of atmospheric carbon dioxide. Perform a blank determination. Calculate the percentage of ethyl vanillin (C9H10O3) in the Sample taken:
Result = {[(VS VB) × N × F]/W} × 100
Acceptance criteria:
98.0%101.0% on the previously dried basis
IMPURITIES
• Residue on Ignition 281:
NMT 0.1%
SPECIFIC TESTS
• Melting Range or Temperature 741:
7678
• Loss on Drying 731:
Dry a sample over phosphorus pentoxide for 4 h: it loses NMT 1.0% of its weight.
ADDITIONAL REQUIREMENTS
• Packaging and Storage:
Preserve in tight, light-resistant containers.
Auxiliary Information
Please check for your question in the FAQs before contacting USP.
USP35NF30 Page 1794
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