Aminobenzoic Acid Topical Solution
» Aminobenzoic Acid Topical Solution contains, in each mL, not less than 45 mg and not more than 55 mg of aminobenzoic acid (C7H7NO2).
Packaging and storage—
Preserve in tight, light-resistant containers.
Identification—
A:
To 1 mL of Topical Solution add 1 mL of 1 N sodium hydroxide, and add, in the order named, 0.5 mL of potassium iodide TS, 0.5 mL of 3 N hydrochloric acid, and 0.5 mL of sodium hypochlorite TS: a brown precipitate is formed.
B:
To 1 mL of Topical Solution add 2 mL of 3 N hydrochloric acid, and cool to about 10
. Add 1 mL of sodium nitrite solution (1 in 100), then add a solution prepared by mixing 50 mg of 2-naphthol with 3 mL of sodium hydroxide solution (1 in 10): a red color is produced.
. Add 1 mL of sodium nitrite solution (1 in 100), then add a solution prepared by mixing 50 mg of 2-naphthol with 3 mL of sodium hydroxide solution (1 in 10): a red color is produced.
Specific gravity 
841
:
not less than 0.895 and not more than 0.905.
841:
not less than 0.895 and not more than 0.905.
Alcohol content 611:
between 65% and 75% of C2H5OH.
611:
between 65% and 75% of C2H5OH.
Assay—
Transfer 5 mL of Topical Solution, accurately measured, to a suitable open vessel, evaporate on a steam bath to dryness, and proceed as directed under Nitrite Titration 451, beginning with “Add 20 mL of hydrochloric acid.” Each mL of 0.1 M sodium nitrite is equivalent to 13.71 mg of C7H7NO2.
451, beginning with “Add 20 mL of hydrochloric acid.” Each mL of 0.1 M sodium nitrite is equivalent to 13.71 mg of C7H7NO2.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
|---|---|---|
| Monograph | Feiwen Mao, M.S.
Senior Scientific Liaison 1-301-816-8320 |
(SM32010) Monographs - Small Molecules 3 |
USP35–NF30 Page 2167