(klor' oh kwin).
» Chloroquine contains not less than 98.0 percent and not more than 102.0 percent of C18H26ClN3, calculated on the dried basis.
Packaging and storage Preserve in well-closed containers. Store at 25, excursions permitted between 15 and 30.
USP Reference standards 11
A: Dissolve 35 mg in 4 mL of chloroform, and pass through a dry filter: the IR absorption spectrum of the solution so obtained exhibits maxima only at the same wavelengths as that of a solution of USP Chloroquine Phosphate RS prepared as directed in Identification test A under Chloroquine Phosphate.
B: Ultraviolet Absorption 197U
Solution: 10 µg per mL.
Medium: dilute hydrochloric acid (1 in 1000).
Ratio: A343 / A329, between 1.00 and 1.15.
Melting range 741: between 87 and 92.
Loss on drying 731 Dry it at 105 for 2 hours: it loses not more than 2.0% of its weight.
Residue on ignition 281: not more than 0.2%.
Assay Dissolve about 250 mg of Chloroquine, accurately weighed, in 50 mL of glacial acetic acid, add crystal violet TS, and titrate with 0.1 N perchloric acid VS. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 15.99 mg of C18H26ClN3.
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USP35NF30 Page 2630Pharmacopeial Forum: Volume No. 34(1) Page 86