Chloroquine
(klor' oh kwin).
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319.871,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-.
7-Chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline
[54-05-7].» Chloroquine contains not less than 98.0 percent and not more than 102.0 percent of C18H26ClN3, calculated on the dried basis.
Packaging and storage—
Preserve in well-closed containers. Store at 25
, excursions permitted between 15 and 30.
, excursions permitted between 15 and 30.
USP Reference standards 
11
—
11—
USP Chloroquine Phosphate RS 
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Identification—
A:
Dissolve 35 mg in 4 mL of chloroform, and pass through a dry filter: the IR absorption spectrum of the solution so obtained exhibits maxima only at the same wavelengths as that of a solution of USP Chloroquine Phosphate RS prepared as directed in Identification test A under Chloroquine Phosphate.
B: Ultraviolet Absorption 197U—
197U—
Solution:
10 µg per mL.
Medium:
dilute hydrochloric acid (1 in 1000).
Ratio:
A343 / A329, between 1.00 and 1.15.
Melting range 741:
between 87 and 92.
741:
between 87 and 92.
Loss on drying 731—
Dry it at 105 for 2 hours: it loses not more than 2.0% of its weight.
731—
Dry it at 105 for 2 hours: it loses not more than 2.0% of its weight.
Residue on ignition 281:
not more than 0.2%.
281:
not more than 0.2%.
Assay—
Dissolve about 250 mg of Chloroquine, accurately weighed, in 50 mL of glacial acetic acid, add crystal violet TS, and titrate with 0.1 N perchloric acid VS. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 15.99 mg of C18H26ClN3.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
|---|---|---|
| Monograph | Behnam Davani, Ph.D., M.B.A.
Senior Scientific Liaison 1-301-816-8394 |
(SM12010) Monographs - Small Molecules 1 |
| Reference Standards | RS Technical Services 1-301-816-8129 rstech@usp.org |
USP35–NF30 Page 2630
Pharmacopeial Forum: Volume No. 34(1) Page 86