Carbachol
(kar' ba kol).
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182.65Ethanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-, chloride.
Choline chloride, carbamate
[51-83-2].» Carbachol contains not less than 99.0 percent and not more than 101.0 percent of C6H15ClN2O2, calculated on the dried basis.
Packaging and storage—
Preserve in tight containers.
USP Reference standards 
11
—
11—
USP Carbachol RS 
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Identification—
B:
A solution (1 in 20) meets the requirements for the silver nitrate precipitate test for Chloride 191.
191.
Melting range 741:
between 200
and 204, with some decomposition.
741:
between 200 and 204, with some decomposition.
Loss on drying 731—
Dry about 1 g, accurately weighed, at 105 for 2 hours: it loses not more than 2.0% of its weight.
731—
Dry about 1 g, accurately weighed, at 105 for 2 hours: it loses not more than 2.0% of its weight.
Residue on ignition 281:
not more than 0.1%.
281:
not more than 0.1%.
Ordinary impurities 466—
466—
Test solution:
a mixture of methanol and water (4:1).
Standard solution:
a mixture of methanol and water (4:1).
Eluant:
alcohol.
Visualization:
16.
Assay—
Dissolve about 400 mg of Carbachol, accurately weighed, in a mixture of 10 mL of glacial acetic acid and 10 mL of mercuric acetate TS. Add 2 drops of crystal violet TS, and titrate with 0.1 N perchloric acid VS. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 18.27 mg of C6H15ClN2O2.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
|---|---|---|
| Monograph | Ravi Ravichandran, Ph.D.
Principal Scientific Liaison 1-301-816-8330 |
(SM42010) Monographs - Small Molecules 4 |
| Reference Standards | RS Technical Services 1-301-816-8129 rstech@usp.org |
USP35–NF30 Page 2480
Pharmacopeial Forum: Volume No. 33(2) Page 213