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C22H19NO4 361.39

Phenol, 4,4¢-(2-pyridinylmethylene)bis-, diacetate (ester).
4,4¢-(2-Pyridylmethylene)diphenol diacetate (ester) [603-50-9].
» Bisacodyl contains not less than 98.0 percent and not more than 101.0 percent of C22H19NO4, calculated on the dried basis.
Caution—Avoid inhalation and contact with the eyes, skin, and mucous membranes.
Packaging and storage— Preserve in well-closed containers.
A: Infrared Absorption 197S
Cell: 1.0 mm.
Solution: 1 in 200 solution in chloroform, previously dried.
B: Ultraviolet Absorption 197U
Solution: 20 µg per mL.
Medium: 0.05 N hydrochloric acid.
Absorptivities at 263 nm, calculated on the dried basis, do not differ by more than 3.0%.
Melting range 741: between 131 and 135.
Loss on drying 731 Dry it at 105 for 2 hours: it loses not more than 0.5% of its weight.
Residue on ignition 281: not more than 0.1%.
Assay— Dissolve about 250 mg of Bisacodyl, accurately weighed, in 70 mL of glacial acetic acid, add 3 drops of p-naphtholbenzein TS, and titrate with 0.1 N perchloric acid VS. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 36.14 mg of C22H19NO4.
Auxiliary Information— Please check for your question in the FAQs before contacting USP.
Topic/Question Contact Expert Committee
Monograph Elena Gonikberg, Ph.D.
Senior Scientist
(MDGRE05) Monograph Development-Gastrointestinal Renal and Endocrine
Reference Standards Lili Wang, Technical Services Scientist
USP32–NF27 Page 1682