Xanthan Gum Solution
» Prepare Xanthan Gum Solution of the designated percentage strength as follows (see Pharmaceutical Compounding—Nonsterile Preparations 795):
Xanthan Gum
for 0.1% Solution
100 mg
for 1.0% Solution 1.0 g
Methylparaben 100 mg
Propylparaben 20 mg
Purified Water, a sufficient quantity to make 100 mL
Dissolve an accurately weighed quantity of Propylparaben in Purified Water with heating to about 50 and stirring. Cool, and dilute quantitatively, and stepwise if necessary, with Purified Water to obtain 90 mL of solution containing 20 mg of Propylparaben. Heat to about 50, and add the Methylparaben, with stirring, to dissolve. Cool, stir with a blender, slowly sift the Xanthan Gum into the vortex, and continue to blend for 2 minutes after the Xanthan Gum has been added. Add 10 mL of Purified Water, and blend for 5 minutes. Allow to stand for 1 hour for excess foam to subside, and remove most of the remaining foam by passing the solution through a strainer. Add Purified Water, if necessary, to make the final volume 100 mL, and stir. [note—Depending on the volume needed and the equipment available, adjust the formula proportionately.]
Packaging and storage— Preserve in tight, light-resistant containers, and store at controlled room temperature.
Labeling— Label it to state, as part of the official title, the percentage content of xanthan gum.
Beyond-use date— Six weeks after the day on which it was compounded.
Auxiliary Information— Please check for your question in the FAQs before contacting USP.
Topic/Question Contact Expert Committee
Monograph Hong Wang, Ph.D.
Scientist
1-301-816-8351
(EM205) Excipient Monographs 2
USP32–NF27 Page 1379
Pharmacopeial Forum: Volume No. 28(2) Page 429