Sodium Salicylate
160.10Benzoic acid, 2-hydroxy-, monosodium salt.
Monosodium salicylate
[54-21-7].» Sodium Salicylate contains not less than 99.5 percent and not more than 100.5 percent of C7H5NaO3, calculated on the anhydrous basis.
Packaging and storage—
Preserve in well-closed, light-resistant containers.
Water, Method I 
921
:
not more than 0.5%.
921:
not more than 0.5%.
Sulfite or thiosulfate—
Add 1 mL of hydrochloric acid to a solution of 1.0 g in 20 mL of water, and filter the liquid: not more than 0.15 mL of 0.10 N iodine is required to produce a yellow color in the filtrate.
Heavy metals, Method I 231—
Dissolve 2 g in 46 mL of water. Add, with constant stirring, 4 mL of 3 N hydrochloric acid, filter, and use 25 mL of the filtrate: the limit is 0.002%.
231—
Dissolve 2 g in 46 mL of water. Add, with constant stirring, 4 mL of 3 N hydrochloric acid, filter, and use 25 mL of the filtrate: the limit is 0.002%.
Assay—
Transfer about 700 mg of Sodium Salicylate, accurately weighed, to a 250-mL beaker. Add 100 mL of glacial acetic acid, stir until the sample is completely dissolved, add crystal violet TS, and titrate with 0.1 N perchloric acid VS. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 16.01 mg of C7H5NaO3.
Auxiliary Information—
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Chromatographic Column—
| Topic/Question | Contact | Expert Committee |
| Monograph | Clydewyn M. Anthony, Ph.D.
Scientist 1-301-816-8139 |
(MDCCA05) Monograph Development-Cough Cold and Analgesics |
USP32–NF27 Page 3584
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.