Sodium Propionate
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Propanoic acid, sodium salt, hydrate.
Sodium propionate hydrate [6700-17-0].

Anhydrous 96.06 [137-40-6].
» Sodium Propionate, dried at 105 for 2 hours, contains not less than 99.0 percent and not more than 100.5 percent of C3H5NaO2.
Packaging and storage— Preserve in tight containers.
A: Infrared Absorption 197K, on undried specimen.
B: A solution (1 in 20) responds to the tests for Sodium 191.
Alkalinity— Dissolve 2.0 g in 20 mL of water, and add phenolphthalein TS: if a pink color is produced, it is discharged by 0.60 mL of 0.10 N sulfuric acid.
Water, Method I 921: not more than 1.0%.
Heavy metals, Method I 231 Dissolve 2 g in 1 mL of 1 N acetic acid and sufficient water to make 25 mL: the limit is 0.001%.
Assay— Dissolve about 200 mg of Sodium Propionate, previously dried at 105 for 2 hours and accurately weighed, in 50 mL of glacial acetic acid. Add 1 drop of crystal violet TS, and titrate with 0.1 N perchloric acid VS to a green endpoint. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 9.606 mg of C3H5NaO2.
Auxiliary Information— Please check for your question in the FAQs before contacting USP.
Topic/Question Contact Expert Committee
Monograph Robert H. Lafaver, B.A.
(EM105) Excipient Monographs 1
Reference Standards Lili Wang, Technical Services Scientist
USP32–NF27 Page 1345
Chromatographic Column—
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.