Benoxinate Hydrochloride
344.88Benzoic acid, 4-amino-3-butoxy-, 2-(diethylamino)ethyl ester, monohydrochloride.
2-(Diethylamino)ethyl 4-amino-3-butoxybenzoate monohydrochloride
[5987-82-6].» Benoxinate Hydrochloride contains not less than 98.5 percent and not more than 101.5 percent of C17H28N2O3·HCl, calculated on the dried basis.
Packaging and storage—
Preserve in well-closed containers.
Identification—
A:
Infrared Absorption 
197K
: previously dried.
197K: previously dried.
Solution:
15 µg per mL.
Medium:
water.
C:
A solution (1 in 100) responds to the tests for Chloride 191.
191.
pH 791:
between 5.0 and 6.0, in a solution (1 in 100).
791:
between 5.0 and 6.0, in a solution (1 in 100).
Loss on drying 731—
Dry it at 105
for 3 hours: it loses not more than 1.0% of its weight.
731—
Dry it at 105 for 3 hours: it loses not more than 1.0% of its weight.
Residue on ignition 281:
not more than 0.2%.
281:
not more than 0.2%.
Ordinary impurities 466—
466—
Test solution:
methanol.
Standard solution:
methanol.
Eluant:
a mixture of chloroform, cyclohexane, and diethylamine (5:4:1).
Visualization:
12.
Assay—
Dissolve about 250 mg of Benoxinate Hydrochloride, accurately weighed, in a mixture of 20 mL of glacial acetic acid and 20 mL of acetic anhydride, and titrate with 0.1 N perchloric acid VS, determining the endpoint potentiometrically. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 34.49 mg of C17H28N2O3·HCl.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
| Monograph | Daniel K. Bempong, Ph.D.
Senior Scientist 1-301-816-8143 |
(MDPS05) Monograph Development-Pulmonary and Steroids |
| Reference Standards | Lili Wang, Technical Services Scientist 1-301-816-8129 RSTech@usp.org |
USP32–NF27 Page 1638