Sodium Bicarbonate Tablets
» Sodium Bicarbonate Tablets contain not less than 95.0 percent and not more than 105.0 percent of the labeled amount of NaHCO3.
Packaging and storage Preserve in well-closed containers.
Disintegration 701: 30 minutes, simulated gastric fluid TS being substituted for water in the test.
Uniformity of dosage units 905: meet the requirements.
Assay Weigh and finely powder not less than 20 Tablets. Weigh accurately a portion of the powder, equivalent to about 2 g of sodium bicarbonate, dissolve in 100 mL of water, add methyl red TS, and titrate with 1 N hydrochloric acid VS. Add the acid slowly, with constant stirring, until the solution becomes faintly pink. Heat the solution to boiling, cool, and continue the titration until the pink color no longer fades after boiling. Each mL of 1 N hydrochloric acid is equivalent to 84.01 mg of NaHCO3.
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USP32NF27 Page 3566