» Sodium Ascorbate contains not less than 99.0 percent and not more than 101.0 percent of C6H7NaO6, calculated on the dried basis.
Packaging and storage Preserve in tight, light-resistant containers.
A: Infrared Absorption 197M, on undried specimen.
B: Add 1 mL of 0.1 N hydrochloric acid to 4 mL of a solution (1 in 50): the solution reduces alkaline cupric tartrate TS slowly at room temperature but more readily upon heating.
C: A solution (1 in 50) responds to the tests for Sodium 191.
Specific rotation 781S: between +103 and +108, determined immediately following the preparation of the solution.
Test solution: 100 mg per mL, in carbon dioxide-free water.
pH 791: between 7.0 and 8.0, in a solution (1 in 10).
Loss on drying 731 Dry it in a suitable vacuum drying tube, phosphorus pentoxide being used as the desiccant, at 60 for 4 hours: it loses not more than 0.25% of its weight.
Heavy metals, Method II 231: 0.002%.
Assay Dissolve about 400 mg of Sodium Ascorbate, accurately weighed, in a mixture of 100 mL of carbon dioxide-free water and 25 mL of 2 N sulfuric acid. Titrate immediately with 0.1 N iodine VS, adding 3 mL of starch TS as the endpoint is approached. Each mL of 0.1 N iodine is equivalent to 9.905 mg of C6H7NaO6.
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USP32NF27 Page 3563
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.