Protriptyline Hydrochloride
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C19H21N·HCl 299.84

5H-Dibenzo[a,d]cycloheptene-5-propanamine, N-methyl-, hydrochloride.
N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine hydrochloride [1225-55-4].
» Protriptyline Hydrochloride contains not less than 99.0 percent and not more than 101.0 percent of C19H21N·HCl, calculated on the dried basis.
Packaging and storage— Preserve in well-closed containers.
USP Reference standards 11
USP Protriptyline Hydrochloride RS
Solution: 10 µg per mL.
Medium: 0.1 N methanolic hydrochloric acid.
Absorptivities at 292 nm, calculated on the dried basis, do not differ by more than 3.0%.
C: It responds to the test for Chloride 191, when tested as specified for alkaloidal hydrochlorides.
D: Its X-ray diffraction pattern (see X-ray Diffraction 941) conforms to that of USP Protriptyline Hydrochloride RS.
pH 791: between 5.0 and 6.5, in a solution (1 in 100).
Loss on drying 731 Dry it at a pressure below 5 mm of mercury at 60 to constant weight: it loses not more than 0.3% of its weight.
Residue on ignition 281: not more than 0.1%.
Assay— Transfer about 700 mg of Protriptyline Hydrochloride, accurately weighed, to a 125-mL conical flask, and dissolve in 30 mL of glacial acetic acid. Add crystal violet TS and 10 mL of mercuric acetate TS, and titrate with 0.1 N perchloric acid VS to a green endpoint. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 29.98 mg of C19H21N·HCl.
Auxiliary Information— Please check for your question in the FAQs before contacting USP.
Topic/Question Contact Expert Committee
Monograph Ravi Ravichandran, Ph.D.
Senior Scientist
(MDPP05) Monograph Development-Psychiatrics and Psychoactives
Reference Standards Lili Wang, Technical Services Scientist
USP32–NF27 Page 3437
Chromatographic Column—
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.