Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]-, monohydrochloride.
N-Isopropyl--(2-methylhydrazino)-p-toluamide monohydrochloride [366-70-1].
» Procarbazine Hydrochloride contains not less than 98.5 percent and not more than 100.5 percent of C12H19N3O·HCl.
Caution: Handle Procarbazine Hydrochloride with exceptional care, since it is a highly potent agent.
Packaging and storage Preserve in tight, light-resistant containers.
B: Ultraviolet Absorption 197U[noteUse low-actinic glassware throughout this test.]
Solution: 10 µg per mL.
Medium: 0.1 N hydrochloric acid.
Absorptivities at 232 nm do not differ by more than 3.0%.
Residue on ignition 281: not more than 0.1%.
Heavy metals, Method II 231: 0.002%.
Assay Dissolve about 0.75 g of Procarbazine Hydrochloride, accurately weighed, in 100 mL of water. Titrate with 0.1 N sodium hydroxide VS, determining the endpoint potentiometrically, using a calomel-glass electrode system. Each mL of 0.1 N sodium hydroxide is equivalent to 25.78 mg of C12H19N3O·HCl.
Auxiliary Information Please check for your question in the FAQs before contacting USP.Chromatographic Column
USP32NF27 Page 3394
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.