Procarbazine Hydrochloride
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C12H19N3O·HCl 257.76

Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]-, monohydrochloride.
N-Isopropyl--(2-methylhydrazino)-p-toluamide monohydrochloride [366-70-1].
» Procarbazine Hydrochloride contains not less than 98.5 percent and not more than 100.5 percent of C12H19N3O·HCl.
Caution: Handle Procarbazine Hydrochloride with exceptional care, since it is a highly potent agent.
Packaging and storage— Preserve in tight, light-resistant containers.
B: Ultraviolet Absorption 197U[note—Use low-actinic glassware throughout this test.]
Solution: 10 µg per mL.
Medium: 0.1 N hydrochloric acid.
Absorptivities at 232 nm do not differ by more than 3.0%.
Residue on ignition 281: not more than 0.1%.
Assay— Dissolve about 0.75 g of Procarbazine Hydrochloride, accurately weighed, in 100 mL of water. Titrate with 0.1 N sodium hydroxide VS, determining the endpoint potentiometrically, using a calomel-glass electrode system. Each mL of 0.1 N sodium hydroxide is equivalent to 25.78 mg of C12H19N3O·HCl.
Auxiliary Information— Please check for your question in the FAQs before contacting USP.
Topic/Question Contact Expert Committee
Monograph Feiwen Mao, M.S.
(MDOOD05) Monograph Development-Ophthalmics Oncologics and Dermatologicals
Reference Standards Lili Wang, Technical Services Scientist
USP32–NF27 Page 3394
Chromatographic Column—
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.