Potassium Chloride
KCl
74.55
Potassium chloride. Potassium chloride [7447-40-7]. » Potassium Chloride contains not less than 99.0 percent and not more than 100.5 percent of KCl, calculated on the dried basis.
Packaging and storage
Preserve in well-closed containers.
Labeling
Where Potassium Chloride is intended for use in hemodialysis, it is so labeled.
Acidity or alkalinity
To a solution of 5.0 g in 50 mL of carbon dioxidefree water add 3 drops of phenolphthalein TS: no pink color is produced. Then add 0.30 mL of 0.020 N sodium hydroxide: a pink color is produced.
Loss on drying 731
Dry it at 105 for 2 hours: it loses not more than 1.0% of its weight.
Iodide or bromide
iodide
Standard stock solution
Transfer an accurately weighed quantity, about 41 mg, of potassium iodide to a 25-mL volumetric flask. Dissolve in and dilute with water to volume, and mix.
Standard solution
Dilute 1.0 mL of Standard stock solution with water to 25 mL, and mix. Dilute 2.0 mL of this solution with water to 8 mL, and proceed as directed for Test solution beginning with Add 1 mL each of chloroform.
Test solution
Dissolve 2 g of Potassium Chloride in 8 mL of water. Add 1 mL each of chloroform and diluted hydrochloric acid, then add 2 drops of a chloramine T solution (0.1 in 100), and shake gently. The violet color of the chloroform layer is not darker than that of a concomitantly prepared Standard solution: the limit is 0.005%.
bromide
Standard solution
Transfer an accurately weighed quantity, about 32 mg, of sodium bromide to a 25-mL volumetric flask. Dissolve in and dilute with water to volume, and mix. Dilute 2.0 mL of this solution with water to 8 mL, and proceed as directed for Test solution beginning with Add 1 mL each of chloroform.
Test solution
Dissolve 2 g of Potassium Chloride in 8 mL of water. Add 1 mL each of chloroform and diluted hydrochloric acid, then add 5 drops of a chloramine T solution (1 in 100), and shake gently. The brown color of the chloroform layer is not darker than that of a concomitantly prepared Standard solution: the limit is 0.1%.
Aluminum 206 (where it is labeled as intended for use in hemodialysis)
Proceed as directed using 2.0 g of Potassium Chloride to prepare the Test Preparation: the limit is 1 µg per g.
Calcium and magnesium
To 20 mL of a solution (1 in 100) add 2 mL each of 6 N ammonium hydroxide, ammonium oxalate TS, and dibasic sodium phosphate TS: no turbidity is produced within 5 minutes.
Sodium
A solution (1 in 20), tested on a platinum wire, does not impart a pronounced yellow color to a nonluminous flame.
Heavy metals 231
Dissolve 2.0 g in 25 mL of water: the limit is 0.001%.
Assay
Dissolve about 200 mg of Potassium Chloride, accurately weighed, in 10 mL of water. Add 10 mL of glacial acetic acid, 75 mL of methanol, and 3 drops of eosin Y TS. Titrate, with shaking, with 0.1 N silver nitrate VS to a pink endpoint. Each mL of 0.1 N silver nitrate is equivalent to 7.455 mg of KCl.
Auxiliary Information
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Chromatographic Column
USP32NF27 Page 3336
Pharmacopeial Forum: Volume No. 29(5) Page 1562
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.
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