Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride.
N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride [63-92-3].
» Phenoxybenzamine Hydrochloride contains not less than 98.0 percent and not more than 101.0 percent of C18H22ClNO·HCl, calculated on the dried basis.
Packaging and storage Preserve in well-closed containers.
Solution: 1 mg per mL.
Absorptivities at 275 nm, calculated on the dried basis, do not differ by more than 3.0%.
Melting range, Class I 741: between 136 and 141.
Loss on drying 731 Dry it in vacuum at 60 for 2 hours: it loses not more than 0.5% of its weight.
Ordinary impurities 466
Test solution: methanol.
Standard solution: methanol.
Eluant: a mixture of toluene and acetone (1:1).
Assay Dissolve about 500 mg of Phenoxybenzamine Hydrochloride, accurately weighed, in 50 mL of glacial acetic acid, add 15 mL of mercuric acetate TS, and titrate with 0.1 N perchloric acid VS, determining the endpoint potentiometrically. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 34.03 mg of C18H22ClNO·HCl.
Auxiliary Information Please check for your question in the FAQs before contacting USP.Chromatographic Column
USP32NF27 Page 3274
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.