Phenoxybenzamine Hydrochloride
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C18H22ClNO·HCl 340.29

Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride.
N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride [63-92-3].
» Phenoxybenzamine Hydrochloride contains not less than 98.0 percent and not more than 101.0 percent of C18H22ClNO·HCl, calculated on the dried basis.
Packaging and storage— Preserve in well-closed containers.
Solution: 1 mg per mL.
Medium: methanol.
Absorptivities at 275 nm, calculated on the dried basis, do not differ by more than 3.0%.
Melting range, Class I 741: between 136 and 141.
Loss on drying 731 Dry it in vacuum at 60 for 2 hours: it loses not more than 0.5% of its weight.
Ordinary impurities 466
Test solution: methanol.
Standard solution: methanol.
Eluant: a mixture of toluene and acetone (1:1).
Visualization: 1.
Assay— Dissolve about 500 mg of Phenoxybenzamine Hydrochloride, accurately weighed, in 50 mL of glacial acetic acid, add 15 mL of mercuric acetate TS, and titrate with 0.1 N perchloric acid VS, determining the endpoint potentiometrically. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 34.03 mg of C18H22ClNO·HCl.
Auxiliary Information— Please check for your question in the FAQs before contacting USP.
Topic/Question Contact Expert Committee
Monograph Sujatha Ramakrishna, Ph.D.
(MDCV05) Monograph Development-Cardiovascular
Reference Standards Lili Wang, Technical Services Scientist
USP32–NF27 Page 3274
Chromatographic Column—
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.