Ascorbyl Palmitate
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C22H38O7 414.53

l-Ascorbic acid, 6-hexadecanoate.
l-Ascorbic acid 6-palmitate [137-66-6].
» Ascorbyl Palmitate contains not less than 95.0 percent and not more than 100.5 percent of C22H38O7, calculated on the dried basis.
Packaging and storage— Preserve in tight containers, in a cool, dry place.
Identification— Dissolve 1 g in 25 mL of alcohol, and add 1 mL of a 1 in 1000 solution of 2,6-dichlorophenol-indophenol sodium in alcohol: the blue color of the 2,6-dichlorophenol-indophenol sodium solution is discharged immediately.
Melting range 741: between 107 and 117.
Specific rotation 781S: between +21 and +24.
Test solution: 100 mg per mL, in methanol.
Loss on drying 731 Dry it in vacuum at 60 for 1 hour: it loses not more than 2.0% of its weight.
Residue on ignition 281: not more than 0.1%.
Assay— Dissolve about 300 mg of Ascorbyl Palmitate, accurately weighed, in 50 mL of alcohol, add 30 mL of water, and immediately titrate with 0.1 N iodine VS to a yellow color that persists for not less than 30 seconds. Each mL of 0.1 N iodine is equivalent to 20.73 mg of C22H38O7.
Auxiliary Information— Please check for your question in the FAQs before contacting USP.
Topic/Question Contact Expert Committee
Monograph Robert H. Lafaver, B.A.
(EM105) Excipient Monographs 1
USP32–NF27 Page 1167
Chromatographic Column—
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.