Ascorbyl Palmitate

C22H38O7

414.53

l-Ascorbic acid, 6-hexadecanoate.
l-Ascorbic acid 6-palmitate

[137-66-6].

» Ascorbyl Palmitate contains not less than 95.0 percent and not more than 100.5 percent of C22H38O7, calculated on the dried basis.

Packaging and storage— Preserve in tight containers, in a cool, dry place.

Identification— Dissolve 1 g in 25 mL of alcohol, and add 1 mL of a 1 in 1000 solution of 2,6-dichlorophenol-indophenol sodium in alcohol: the blue color of the 2,6-dichlorophenol-indophenol sodium solution is discharged immediately.

Melting range

741

: between 107

and 117

Specific rotation

781S

: between +21

and +24

Test solution: 100 mg per mL, in methanol.

Loss on drying

731

— Dry it in vacuum at 60

for 1 hour: it loses not more than 2.0% of its weight.

Residue on ignition

281

: not more than 0.1%.

Heavy metals, Method II

231

: 0.001%.

Assay— Dissolve about 300 mg of Ascorbyl Palmitate, accurately weighed, in 50 mL of alcohol, add 30 mL of water, and immediately titrate with 0.1 N iodine VS to a yellow color that persists for not less than 30 seconds. Each mL of 0.1 N iodine is equivalent to 20.73 mg of C22H38O7.

Auxiliary Information— Please check for your question in the FAQs before contacting USP.

Topic/Question	Contact	Expert Committee
Monograph	Robert H. Lafaver, B.A. Scientist 1-301-816-8335	(EM105) Excipient Monographs 1

USP32–NF27 Page 1167

Chromatographic Column—

ASCORBYL PALMITATE

Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.