Paromomycin Oral Solution
» Paromomycin Oral Solution contains an amount of Paromomycin Sulfate equivalent to not less than 90.0 percent and not more than 130.0 percent of the labeled amount of paromomycin (C23H45N5O14). It may contain one or more suitable buffers, colors, flavors, preservatives, and solvents.
Packaging and storage— Preserve in tight containers.
Uniformity of dosage units 905
for oral solution packaged in single-unit containers: meets the requirements.
Deliverable volume 698: meets the requirements.
pH 791: between 7.5 and 8.5.
Assay— Proceed with Oral Solution as directed under Antibiotics—Microbial Assays 81, diluting an accurately measured volume of Oral Solution with Buffer No. 3 to yield a stock solution of convenient concentration. Quantitatively dilute this stock solution with the same buffer to obtain a Test Dilution having a concentration assumed to be equal to the median dose level of the Standard.
Auxiliary Information— Please check for your question in the FAQs before contacting USP.
Topic/Question Contact Expert Committee
Monograph Ahalya Wise, M.S.
(MDANT05) Monograph Development-Antibiotics
Reference Standards Lili Wang, Technical Services Scientist
USP32–NF27 Page 3214
Pharmacopeial Forum: Volume No. 28(2) Page 342