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C15H11ClN2O2 286.71

2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-, (±)-.
(±)-7-Chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one [604-75-1].
» Oxazepam contains not less than 98.0 percent and not more than 102.0 percent of C15H11ClN2O2, calculated on the dried basis.
Packaging and storage— Preserve in well-closed containers.
B: Ultraviolet Absorption 197U
Solution: 4 µg per mL.
Medium: alcohol.
Absorptivities at 229 nm, calculated on the dried basis, do not differ by more than 3.0%.
pH 791: between 4.8 and 7.0, in an aqueous suspension (1 in 50).
Loss on drying 731 Dry it at a pressure below 5 mm of mercury at 105 for 3 hours: it loses not more than 2.0% of its weight.
Residue on ignition 281: not more than 0.3%.
Assay— Transfer about 400 mg of Oxazepam, accurately weighed, to a beaker, dissolve in 100 mL of dimethylformamide, and titrate with 0.1 N tetrabutylammonium hydroxide VS, determining the endpoint potentiometrically using a calomel-glass electrode system and taking precautions against absorption of atmospheric carbon dioxide. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N tetrabutylammonium hydroxide is equivalent to 28.67 mg of C15H11ClN2O2.
Auxiliary Information— Please check for your question in the FAQs before contacting USP.
Topic/Question Contact Expert Committee
Monograph Ravi Ravichandran, Ph.D.
Senior Scientist
(MDPP05) Monograph Development-Psychiatrics and Psychoactives
Reference Standards Lili Wang, Technical Services Scientist
USP32–NF27 Page 3154
Chromatographic Column—
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.