Octoxynol 9
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Poly(oxy-1,2-ethanediyl), -(octylphenyl)--hydroxy-.
Polyethylene glycol mono(octylphenyl) ether [9002-93-1].
» Octoxynol 9 is an anhydrous liquid mixture consisting chiefly of monooctylphenyl ethers of polyethylene glycols, corresponding to the formula:
in which the average value of n is about 9.
Packaging and storage— Preserve in tight containers.
USP Reference standards 11
USP Octoxynol 9 RS
Identification, Infrared Absorption 197F, on undried specimen.
Cloud point— Weigh 1.00 g into a 250-mL beaker, and add 99 g of water. Dissolve completely by careful heating, while stirring at a constant slow speed with a small-propeller-blade stirrer. Center a thermometer vertically in the solution, and heat rapidly until the entire solution becomes cloudy, then raise the temperature 10. Remove the source of heat, continue stirring, and record the temperature at which the solution becomes sufficiently clear to permit seeing the entire thermometer bulb plainly: the cloud point is between 63 and 69.
Hydroxyl value 401: between 85 and 101.
Water, Method I 921: not more than 0.5%.
Residue on ignition 281: not more than 0.4%.
Heavy metals 231: 0.002%.
Free ethylene oxide— Octoxynol 9 meets the requirements for Free ethylene oxide under Nonoxynol 9 (see USP monograph). In performing the test, substitute the term “Octoxynol 9” for “Nonoxynol 9” wherever it occurs. The limit is 5 ppm.
Limit of dioxane— It meets the requirements for Limit of dioxane under Nonoxynol 9 (see USP monograph).
Auxiliary Information— Please check for your question in the FAQs before contacting USP.
Topic/Question Contact Expert Committee
Monograph Hong Wang, Ph.D.
(EM205) Excipient Monographs 2
Reference Standards Lili Wang, Technical Services Scientist
USP32–NF27 Page 1289
Chromatographic Column—
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.