Glycine, N-benzoyl, compd. with 1,3,5,7-tetraazatricyclo[188.8.131.52,7]decane (1:1).
Hexamethylenetetramine monohippurate [5714-73-8].
» Methenamine Hippurate, dried in vacuum at 60 for 1 hour, contains not less than 95.5 percent and not more than 102.0 percent of C6H12N4·C9H9NO3, and contains not less than 54.0 percent and not more than 58.0 percent of hippuric acid (C9H9NO3).
Packaging and storage Preserve in well-closed containers.
Loss on drying 731 Dry it in vacuum at 60 for 1 hour: it loses not more than 1.0% of its weight.
Residue on ignition 281: not more than 0.1%.
Sulfate Dissolve 200 mg in 10 mL of water, and add 5 drops of 3 N hydrochloric acid and 5 drops of barium chloride TS: no turbidity appears within 1 minute.
Heavy metals, Method II 231: 0.0015%.
Hippuric acid content Transfer about 1 g, accurately weighed, to a 250-mL conical flask, and add 50 mL of water. When solution is complete, add phenolphthalein TS, and titrate with 0.1 N sodium hydroxide VS. Each mL of 0.1 N sodium hydroxide is equivalent to 17.92 of C9H9NO3.
Assay Dissolve about 700 mg of Methenamine Hippurate, accurately weighed, in 50 mL of glacial acetic acid, and titrate with 0.1 N perchloric acid VS, determining the endpoint potentiometrically. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 31.94 mg of C6H12N4·C9H9NO3.
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USP32NF27 Page 2921
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.