Carbonic acid, magnesium salt, basic; or, Carbonic acid, magnesium salt (1:1), hydrate
Magnesium carbonate, basic; or, Magnesium carbonate (1:1) hydrate [23389-33-5].
Anhydrous 84.31 [546-93-0].
» Magnesium Carbonate is a basic hydrated magnesium carbonate or a normal hydrated magnesium carbonate. It contains the equivalent of not less than 40.0 percent and not more than 43.5 percent of magnesium oxide (MgO).
Packaging and storage Preserve in well-closed containers.
Identification When treated with 3 N hydrochloric acid, it dissolves with effervescence, and the resulting solution meets the requirements of the tests for Magnesium 191.
Microbial enumeration tests 61 and Tests for specified microorganisms 62 It meets the requirements of the test for absence of Escherichia coli.
Soluble salts Mix 2.0 g with 100 mL of a mixture of equal volumes of n-propyl alcohol and water. Heat the mixture to the boiling point with constant stirring, cool to room temperature, dilute with water to 100 mL, and filter. Evaporate 50 mL of the filtrate on a steam bath to dryness, and dry at 105 for 1 hour: the weight of the residue does not exceed 10 mg (1.0%).
Acid-insoluble substances Mix 5.0 g with 75 mL of water, add hydrochloric acid in small portions, with agitation, until no more of the magnesium carbonate dissolves, and boil for 5 minutes. If an insoluble residue remains, filter, wash well with water until the last washing is free from chloride, and ignite: the weight of the ignited residue does not exceed 2.5 mg (0.05%).
Arsenic, Method I 211 Prepare the Test Preparation by dissolving 750 mg in 25 mL of 3 N hydrochloric acid. The limit is 4 ppm.
Limit of calcium [noteA commercially available atomic absorption standard solution for calcium may be used where preparation of a calcium standard stock solution is described below. Concentrations of the Standard preparations and the Test preparation may be modified to fit the linear or working range of the instrument.]
Dilute hydrochloric acid Dilute 100 mL of hydrochloric acid with water to 1000 mL.
Lanthanum solution To 58.65 g of lanthanum oxide add 400 mL of water, and add, gradually with stirring, 250 mL of hydrochloric acid. Stir until dissolved, dilute with water to 1000 mL, and mix.
Standard preparations Transfer 249.7 mg of calcium carbonate, previously dried at 300 for 3 hours and cooled in a desiccator for 2 hours, to a 100-mL volumetric flask, dissolve in a minimum amount of hydrochloric acid, dilute with water to volume, and mix. Transfer 1.0, 5.0, 10.0, and 15.0 mL of this stock solution to separate 1000-mL volumetric flasks, each containing 20 mL of Lanthanum solution and 40 mL of Dilute hydrochloric acid, add water to volume, and mix. These Standard preparations contain 1.0, 5.0, 10.0, and 15.0 µg of calcium in each mL, respectively.
Blank solution Transfer 4 mL of Lanthanum solution and 10 mL of Dilute hydrochloric acid to a 200-mL volumetric flask, dilute with water to volume, and mix.
Test preparation Transfer 250 mg of Magnesium Carbonate to a beaker, add 30 mL of Dilute hydrochloric acid, and stir until dissolved, heating if necessary. Transfer the solution so obtained to a 200-mL volumetric flask containing 4 mL of Lanthanum solution, dilute with water to volume, and mix.
Procedure Concomitantly determine the absorbances of the Standard preparations and the Test preparation at the calcium emission line at 422.7 nm with a suitable atomic absorption spectrophotometer (see Spectrophotometry and Light-Scattering 851) equipped with a calcium hollow-cathode lamp and a nitrous oxideacetylene flame, using the Blank solution as the blank. Determine the concentration, C, in µg per mL, of calcium in the Test preparation using the calibration graph. Calculate the content of calcium, in percentage, in the portion of Magnesium Carbonate taken by the formula:
100(0.001CV/W)in which C is as defined above; the multiplier of 0.001 is for conversion of µg per mL to mg per mL; V is the volume, in mL, of the Test preparation; and W is the amount of Magnesium Carbonate, in mg, taken to prepare the Test preparation: the limit is 0.45%.
Heavy metals, Method I 231 Dissolve 0.67 g in 10 mL of 3 N hydrochloric acid in a suitable crucible, and evaporate the solution on a steam bath to dryness. Ignite at 550 ± 25 until all carbonaceous material is consumed. Dissolve the residue in 15 mL of water and 5 mL of hydrochloric acid, and evaporate to dryness. Toward the end of the evaporation, stir frequently to disintegrate the residue so that finally a dry powder is obtained. Dissolve the residue in 20 mL of water, and evaporate in the same manner as before to dryness. Redissolve the residue in 20 mL of water, filter, if necessary, and add to the filtrate 2 mL of 1 N acetic acid and water to make 25 mL: the limit is 0.003%.
Iron 241 Boil 50 mg with 5 mL of 2 N nitric acid for 1 minute. Cool, dilute with water to 45 mL, add 2 mL of hydrochloric acid, and mix: the limit is 0.02%.
Assay Dissolve about 1 g of Magnesium Carbonate, accurately weighed, in 30.0 mL of 1 N sulfuric acid VS, add methyl orange TS, and titrate the excess acid with 1 N sodium hydroxide VS. Record the volume, VA, in mL, of 1 N sodium hydroxide consumed. Perform the blank determination, and record the volume, VB, in mL, of 1 N sodium hydroxide consumed. Calculate the volume, VS, of 1 N sulfuric acid, in mL, consumed by the sample, by the formula:
(VB VA) × NNaOHin which NNaOH is the exact normality of the sodium hydroxide solution. Calculate the volume of 1 N sulfuric acid, VCa, in mL, consumed by calcium which is present in the portion of Magnesium Carbonate taken for the Assay, by the formula:
(W × LCa)/(100 × 20.04)in which W is the weight, in mg, of Magnesium Carbonate taken; LCa is the content of calcium, in percentage, as determined in the test for Limit of calcium; and 20.04 is the weight, in mg, of Ca that is equivalent to each mL of 1 N sulfuric acid. Calculate the percentage of MgO in the portion of Magnesium Carbonate taken by the formula:
100(VS VCa) × 20.15/Win which 20.15 is the weight, in mg, of MgO that is equivalent to each mL of 1 N sulfuric acid; and the other terms are as defined above.
Auxiliary Information Please check for your question in the FAQs before contacting USP.Chromatographic Column
USP32NF27 Page 2828Pharmacopeial Forum: Volume No. 32(6) Page 1719
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.